1 | Page
NAPLEX ANTIBIOTICS2026
LATEST QUESTIONS WITH 100%
VERIFIED SOLUTIONS.
MIC - answer -lowest drug concentration that prevents visibile
microbial growth in 24 hours
gram (+) bacteria species - answer -staph, strep, EC, clostridium,
listeria
which antibiotics exhibit time-dependent killing? - answer -
penicillins, cephalosporins
how can you increase the killing of a time-dependent antibiotic? -
answer -dose more frequently, extend the infusion time
example of concentration-dependent antibiotic? - answer -
aminoglycosides (gentamicin, tobramycin, amikacin)
,2 | Page
what are the bacteriostatic antibiotics (protein synthesis
inhibitors)? - answer -macrolides
aminoglycosides
tetracyclines
clindamycin
linezolid
quinupristin, dalfopristin
what is the MOA of penicillins, cephalosporins, carbapenems, and
vancomycin? - answer -cell wall inhibitors - bactericidal
what general ADRs are the black box warning for
aminoglycosides? - answer -nephrotoxicity and neurotoxicity
what are the aminoglycosides? - answer -tobramycin
gentamicin
amikacin
,3 | Page
what type of nephrotoxicity do aminoglycosides cause? - answer -
ATN - acute tubular necrosis
what weight do you use to dose aminoglycosides? - answer -IBW
(unless TBW is less)
*use ABW if obese ( > 30% IBW)
what organisms are aminoglycosides mainly active against? -
answer -gram (-): GNR, PA
extended interval dosing of the aminoglycosides? - answer -
gent/tobra: 4-7 mg/kg
amikacin: 15-20 mg/kg
*draw random level within 6-16 hours after dose
, 4 | Page
adjust body weight (ABW) formula? - answer -IBW + [0.4(TBW -
IBW)]
desired trough (traditional dosing) for gent/tobra? peak? - answer
-trough: < 2 mcg/mL
peak: 5-10 mcg/mL
amoxicilin brand name - answer -Amoxil
what organisms do the penicillins cover? - answer -mainly gram
(+), some gram (-)
which penicillin is the DOC in acute otitis media? - answer -
amoxicillin
which penicillin has activity against PA? - answer -piperacillin
NAPLEX ANTIBIOTICS2026
LATEST QUESTIONS WITH 100%
VERIFIED SOLUTIONS.
MIC - answer -lowest drug concentration that prevents visibile
microbial growth in 24 hours
gram (+) bacteria species - answer -staph, strep, EC, clostridium,
listeria
which antibiotics exhibit time-dependent killing? - answer -
penicillins, cephalosporins
how can you increase the killing of a time-dependent antibiotic? -
answer -dose more frequently, extend the infusion time
example of concentration-dependent antibiotic? - answer -
aminoglycosides (gentamicin, tobramycin, amikacin)
,2 | Page
what are the bacteriostatic antibiotics (protein synthesis
inhibitors)? - answer -macrolides
aminoglycosides
tetracyclines
clindamycin
linezolid
quinupristin, dalfopristin
what is the MOA of penicillins, cephalosporins, carbapenems, and
vancomycin? - answer -cell wall inhibitors - bactericidal
what general ADRs are the black box warning for
aminoglycosides? - answer -nephrotoxicity and neurotoxicity
what are the aminoglycosides? - answer -tobramycin
gentamicin
amikacin
,3 | Page
what type of nephrotoxicity do aminoglycosides cause? - answer -
ATN - acute tubular necrosis
what weight do you use to dose aminoglycosides? - answer -IBW
(unless TBW is less)
*use ABW if obese ( > 30% IBW)
what organisms are aminoglycosides mainly active against? -
answer -gram (-): GNR, PA
extended interval dosing of the aminoglycosides? - answer -
gent/tobra: 4-7 mg/kg
amikacin: 15-20 mg/kg
*draw random level within 6-16 hours after dose
, 4 | Page
adjust body weight (ABW) formula? - answer -IBW + [0.4(TBW -
IBW)]
desired trough (traditional dosing) for gent/tobra? peak? - answer
-trough: < 2 mcg/mL
peak: 5-10 mcg/mL
amoxicilin brand name - answer -Amoxil
what organisms do the penicillins cover? - answer -mainly gram
(+), some gram (-)
which penicillin is the DOC in acute otitis media? - answer -
amoxicillin
which penicillin has activity against PA? - answer -piperacillin
