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Samenvatting les 5 shock, sepsis en hemostase - KG&IZ

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Samenvatting van les 5 shock, sepsis en hemostase van het vak Kennis Gezondheid & Inzichten in Ziek zijn dat gegeven wordt in de eerste fase van de bachelor kine aan de Kul. Het oude vak was ziekteleer.

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Kennis van gezondheid en inzichten in ziek zijn
Les 5
Overzicht
• Shock
• Sepsis
• Hemostase
Shock
Perfusie:
 Perfusie is doorbloeding van weefsels waardoor zuurstof (O₂) en
voedingsstoffen aan de cellen worden afgegeven en afvalstoffen (zoals
CO₂ en lactaat) worden afgevoerd.
 Perfusie is afhankelijk van bloeddruk: druk die de perfusie aandrijft




Shock:
 Shock is een levensbedreigende circulatoire stoornis die leidt tot Weefsel dat niet
onvoldoende weefselperfusie en daardoor cellulaire hypoxie en bevloeit w, gaat
per definitie
orgaandysfunctie.
afsterven
Hypoxie:
 Toestand waarbij het zuurstofgehalte in de weefsels onvoldoende
Zeer goed bevloeid
is om de cellulaire functies normaal te laten verlopen. orgaan kan ondanks
 Te weinig zuurstof in de weefsels perfusie nog steeds
hypoxie krijgen door
Normale perfusie: zuurstoftekort in bloed

 Adequate zuurstoftoevoer (afhankelijk van)
o Cardiac Output (CO) /Bloeddruk
o Arteriële O₂-inhoud
 Perfusie hangt af van:
o Circulerend volume
o Pompfunctie hart
o Vaattonus / weerstand

, Shock:
 Verstoring van één of meerdere van deze componenten:
o ↓ Preload (volumeprobleem)
o ↓ Contractiliteit (hartprobleem)
o ↓ Afterload (vasodilatatie)

→ Cellulaire gevolgen van shock
- Anaeroob metabolisme
- ATP-depletie
- Ionpompfalen, celzwelling
- Metabole acidose (door toename lactaat)
- Celdood, orgaanschade
→ Types of shock

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Written in
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