Developmental stages and their functions in T cell central development Thymic ageing

Mechanims of non-deletional tolerance in the B and T cell compartments: - Light chain editing - Regulatory cells - Anergy

Old and new stratgies for vaccine development Problems in vaccine development, how they are overcome

How the adaptive immune system eliminates viral infection

The events following B cell binding of antigen, and how this affects B cell activity and fate

The importance of antigen-dependent and -independent signalling in determining B cell transcription factor expression and fate

How autophagy and cell death contribute to cell-intrinsic host defence against pathogens

Chemokine signalling and consequences for leukocytes

Mechanisms of complement activation (alternative, lectin and classical pathways) Functions of complement in innate and adaptive immunity

How pattern recognition receptors of the innate immune system detect nucleic acids