Vriteeshah

Learning outcomes - - Describe the signal hypothesis - Compare and contrast co-translational and post-translational translocation - Propose a model for protein translocation based on the structures of the SecY complex - Describe the biosynthesis of integral membrane proteins

Learning Outcomes - - Distinguish between the roles of GEF, GAP and Ran in nuclear transport - Propose how structures of α and β importins inform how cargo is transported

Learning outcomes: - Understand experiments that led to the hypothesis of trafficking - Compare and contrast vesicle budding via COPI, COPII, and clathrin coats - Explain a molecular mechanism for docking and fusion of transport vesicles

Learning outcomes: - Compare and contrast cytoskeletal components - Explain how filament polarity can be identified and the role it plays in transport

- Compare and contrast different types of cell junctions - Explain how structures of integrin and cadherin inform a molecular mechanism for cell adhesion

Learning outcomes: Describe the general principles of cell signalling (amplification, ligands/receptors, G-proteins/kinases, distance, resetting, etc.), with reference to specific examples such as Nuclear Receptors, GPCRs, and RTKs

Learning outcomes covered: - Understand that the Cell Cycle is a universal feature of dividing cells from yeast to sea urchin to frog oocytes and human cells - Recall the names and order of the phases of the eukaryotic cell cycle and describe what happens in each - Describe how the Cell Cycle is regulated by CDKs and cyclins, and what happens when it becomes deregulated (i.e. cancer)