Fatimaal-suwaidi

Outcomes: - Conceptual Tool kit - Homeotic Mutations - Signalling pathways Understanding of Notch, Wnt, Hedgehog, TGFB family(TGFB, BMP, Nodal, Dpp), RTK family(FGF,EGF, Ephrin, C-kit) You should also appreciate how these signalling pathways regulate gene expression through transcription factors, and understand the key features of these pathways, and the specific aspects of some (e.g. what has to happen for it to change gene expression).

Learning Outcomes Explain the mechanisms that underlie cellularmemory of differentiation. Define nuclear reprogramming and discuss thedifferent methods by which this may be experimentally achieved. Discuss the role of the myogenic regulatoryfactors in muscle differentiation.

Modelling morphogen gradients and pattern formation in development Outcomes: Morphogen gradients Animal coat patterns Chick gastrulation and Simotegenesis and etc..

Developmental stem cell of Cell Movement and migration

Includes Egg activation (the role of Ca2+) in vitro fertilization of mouse eggs PLC localizations and etc...

Outcomes: Pre-implantation development (Mouse) Blastocyst and inner cell mass development Embryonic stem cell derivation Meaning of pluripotency

Pattern formation during vertebrate limb development -Describes the regional organisation and axes of the vertebrate limb. • Describe the organisation of the limb bud. • Outline how placement and identity (prospective forelimb or hindlimb) of the limb buds may be determined. • Discuss how formation of the limb bud is initiated. • Describe development of the limb along the proximodistal axis • Discuss the Progress Zone model and the Two-Signal ...

Body plan of Drosophila Axis Development and more... Establishment of the body plan Continuation of: Homeotic Genes, Polycomb trithorax and chromatin, Identity of somites Very well-informed notes Continuation from Body plan 1: Includes: - Drosophila A/P and D/V Axis development: maternal genes Localisation of maternal factors during oogenesis Early steps in A/P and D/V axis formation require interactions of oocyte with follicle cells - Drosophila A/P and D/V Axis development: Zygotic...

Establishment of the body plan includes: Body plan of Drosophila Axis Development and Homeotic Genes and etc.

Learning outcomes: Define what is meant by hormone Appreciate the wide range of hormones and their origins Discuss the different types of hormone receptors Discuss the hypothalamo-pituatary hormone axes