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1. Segmentation Genes
- Class notes • 7 pages • 2020
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-Describe the hierarchy of gene activity that regulates Drosophila segmentation
-Distinguish and explain methods used to investigate protein vs mRNA expression
-Describe the syncytial nature of the early stages of fly development and understand its significance.
-Understand and describe at the molecular level how the Gap genes regulate the expression of Eve stripe 2
-Make predictions about segment polarity gene expression in a pair-rule mutant embryo or about pair-rule gene expression in a Gap m...
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11. Small Changes Big Differences
- Class notes • 10 pages • 2020
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- Understand how the neural crest contributes to cardiac development and the pathology underlying congenital cardiac abnormalities.
- Explain how certain SNPs might contribute to congenital abnormalities.
- Discuss the evidence that Notch signalling is important during cardiac morphogenesis
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9. Backs & Fronts
- Class notes • 7 pages • 2020
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- Discuss the evidence supporting a role for tinman homologues in heart development
- Discuss the anatomical and molecular evidence supporting the theory of dorsoventral axis inversion during the evolution of protostome and deuterostome lineages.
- Describe the conserved features of Hox gene cluster organisation.
- Appreciate and discuss how changes in the expression and activity of Hox genes have contributed to changes in anatomy during animal evolution.
- Draw conclusions regarding the molecul...
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8. Building Bodies
- Class notes • 7 pages • 2020
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- Describe the different types of animal body symmetry and the main body axes of bilaterally symmetrical animals.
- Describe the features that define diploblasts versus triploblasts.
- Describe the features that define protostomes versus deuterostomes.
- Understand the importance of the Ediacaran and Cambrian fauna in animal evolution.	
- Describe the common features of phylotypic stage chordate embryos.
- Discuss the evidence indicating that Pax6 is a conserved regulator of eye development. 
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12. Epigenetics Introduction
- Class notes • 10 pages • 2020
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- To have gained an understanding of why epigenetics is relevant to development
- To understand that DNA methylation can impact gene expression and be able to describe an experimental approach to test this
- To explain how patterns of DNA methylation can be maintained through DNA replication
- To understand that covalent histone modifications form a code that can impact gene expression
- To explain how some histone modifications can be maintained through DNA replication
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4. Neurogenesis
- Class notes • 6 pages • 2020
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- Describe the experimental evidence supporting a conserved pathway for regulating neurogenesis in animals
- Discuss the conserved function of proneural genes in neurogenesis
- Discuss the conserved function of neurogenic genes in neurogenesis
- Describe the role of lateral inhibition in selecting neural precursors
- Describe the conserved role of notch-delta signalling in mediating lateral inhibition
- Appreciate and discuss the distinct processes of neural induction, neurogenesis and neurulati...
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Complete summary of all lectures of the molecular principles of development course
- Summary • 43 pages • 2020
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All lectures summarized into detail including experimental evidence given during the lectures.
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Molecular Principles of Development: Summary of lectures and self-study assignments, NWI-BB084B
- Summary • 59 pages • 2020
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An extensive summary of the information given during the course Molecular Principles of Development (NWI-BB084B) in English. With images, self-study assignments and developmental processes incorporated and explained.
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Lectures molecular principles of development
- Summary • 51 pages • 2020
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All lectures of the course molecular principles of development (NWI-BB084B) are covered in the document (using powerpoint slides, additional information from the lectures and the book). The book used for this course was: molecular principles of development, the 6th Revised edition. The pictures included are taken from the PowerPoint slides and the book. I passed the course using this document.
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