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NMDA Antagonists - Pain Management Exam 2 | Questions with 100% Correct Answers | Verified
What is the major excitatory neurotransmitter in the CNS? - Glutamate 
Where does Glutamate exert its effects? - Ionotropic glutamate receptors: AMPA, Kainate, 
NMDA 
How do NMDA receptors differ from others? - High calcium permeability, magnesium 
blockade at resting membrane potential, and requirement of a coagonist (glycine) for activation 
What is the structure of an NMDA receptor? - Heterotetrameric: 2 NR1 and 2NR2 subunits. 
Several isotopes exist for each subunit. Composition varies with ...