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Intro to Biochemistry (Murphy 301) CH 1 – 4 Solutions
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November 2024
2024/2025
A+
Intro to Biochemistry (Murphy 301) CH 1 – 4 Solutions
The side chain of histidine has a typical pKa value in the range of 6.5-7.4. However, when analyzing the pKa values in a particular protein, scientists determined that one particular His residue has an unusually low pKa value of 4.8. Which of the following statements correctly explain this anomaly?
1) The microenvironment around a residue can impact its pKa value.
2) A positively charged amino acid must be in close proximity to t...
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