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ASCP CGMBS Exam Study Questions and Answers 2024/2025
BCR;ABL1 fusion protein → t(9;22)(q34;q11) Acute Promyelocytic Leukemia (APL) → t(15;17) a fusion of PML and RARA Burkitt's Lymphoma → t(8;14) the breakpoints on chr.8 are spread of 190 kbp region 5' to and within the CMY C gene Follicular Cell Lymphoma (FCL) → t(14;18) translocation disregulate BCL2, which inhibits apoptosis in B lymphocytes, which leads to survival of genetically damaged cells Mantle Cell (MCL) → t(11;14) translocation increases expression of CCND1 ...
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ASCP CGMBS Exam Study Questions And Answers Rated 100% Correct!!
PopularWarfarin (Coumadin) - ️️CYP2C9 and VKORC1 - Vitamin K antagonist; metabolized primarily via oxidation in the liver by CYP2C9 and exerts its anticoagulant effect by inhibiting the protein vitamin epoxide reductase complex, subunit 1 (VKORC1) Chronic Myelogenous Leukemia (CML) - ️️t(9;22) aka Philadelphia Chromosome, translocation occurs within two genes: the breakpoint cluster region (BCR) on chr.22 and the cellular counter part of the Abelson Leukemia virus tyrosine kinase (c-abl) o...
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