BIOPHARMACEUTICS

This document contains information about the ● Drug dissociation: - pH-partition hypothesis - Henderson-Hasselbalch Equation - Limitations of the pH-partition hypothesis ● Lipid solubility - Partition coefficient ● Molecular size & hydrogen bonding.

drug factors affecting or influencing the rate of dissolution and salt formation, solubility in the diffusion layer, pH partition hypothesis. partition coefficient and lipid solubility. Henderson-Hasselbalch Equation. Limitations of the pH-partition hypothesis. Molecular size & hydrogen bonding.

This document includes detailed information about the factors affecting drug absorption and barriers of drug absorption in the GI tract. It includes factors like GIT diseases, transporters across the membrane, the presence of food in GIT, the physicochemical properties of a drug , dosage forms, and route of administration. Explanation of how each of the factors mentioned affects the absorption, dissolution, and bioavailability of oral drugs.