LIFE305 Cell Signalling in Health and Disease

Lecture of LIFE305 Cell Signalling on immune cell signalling. Covers B-cell development, different types of B cells, V(D)J recombination (in-depth mechanism/overview), class-switch recombination, different classes of immunoglobulins (Igs), different models of B-cell activation (dissociation activation model and crosslinking model), detailed overview of B cell receptor signalling (Syk/Lyn kinase, src-family kinases, protein tyrosine phosphatases), models of proximal BCR signalling (conformational...

Lecture of LIFE305 Cell Signalling on ligand-gated channels, including how ionic flux occurs and how selectivity is achieved, techniques for studying ligand-gated ion channels, and the link between ion channel structure and function. Details on ligand-gated channel (super)families (glutamate receptors, cys-loop receptors, ATP/P2X receptors) and their different structures, roles and functions. Brief overview of neurotransmission. Information on how RNA editing plays a role in the Ca2 -permeabilit...

Lecture of LIFE305 Cell Signalling on phosphatidylinositol 3-kinase signalling. Information on the structure and function of phosphatidylinositols/phosphoinositides and their role in cell signalling. In-depth, step-wise overview of the PI3K pathway with detailed information on the different PI3K isoforms, PI3K signalling regulation by phosphatases/phospholipases, Akt activation, mTOR signalling and PI3K inhibitors.

Lecture notes of LIFE305 Cell Signalling on kinases (e.g. SRC kinase, PKA), phosphatases, ubiquitylation and receptor tyrosine kinases. Lots of background information on the structure and function of these enzymes and their substrates. Also info on protein domains and their role in signalling networks. In-depth info on the ubiquitin cycle.

Lecture notes of LIFE305 Cell Signalling on signalling regulating cell migration, covering the phenotypic aspects of cell migration as well as the signalling pathways and proteins involved (e.g. RhoGTPases).

Lecture notes of LIFE305 Cell Signalling about Sensory signalling in vision, olfaction and gustation. Discusses the signalling pathways from GPCR to output and the proteins involved.