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NM3 Rare Diseases: ALS, PPS, CMT (ALS, Post-Polio, CMT) Questions and Answers 
 
ALS is what type of disease? 
Motor neuron disease that is inherited or sporadic 
(UMN and LMN) 
Most common motor neuron disease? 
ALS (and most commonly limb onset vs bulbar) 
ALS is the degeneration of? 
Motor neurons in SC, brainstem, and brain 
ALS affects what population more? 
Men 
In ALS, 20% of hereditary cases have a defect with the gene encoding? 
Copper-zinc super oxide dismutase 
What areas of the brain...
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