PC 707 Module 1 Questions with Complete
Solutions
What is a pharmacologically inactive medication that are metabolized into the active form within
the body? Pro drug
Ultra-rapid metabolizer (Explain ultra-rapid metabolizers. How do these differ from poor to
intermediate metabolizers?) prodrugs are rapidly metabolized into active drug. Active
drug is rapidly metabolized into inactive metabolite leading to potential therapeutic failure.
Patient requires higher doses of active drug.
What is it when a person has more than one functioning copy of a certain enzyme and metabolize
drugs at a very fast rate? Ultra rapid metabolizer
What inactivates the drug and less will reach the system? Hepatic first-pass
What helps determine the safety of a drug? Half-life
What is it when 50% of the original drug is in the body? Half-life (dosing intervals)
,What is elimination of the drug metabolite in the body? Excretion
What are ways drugs are excreted out of the body? (1) renal (2) saliva (3) skin (4) breast
milk
What is the relationship between a drug's desired therapeutic effects and adverse effects?
Therapeutic drug level
Are lipid soluble drugs easily excreted from the body? No
What is the goal with lipid soluble drugs so that they can be excreted from the body?
Make more water soluble
What is the maximum effect a drug can produce at any dosage? Maximal efficacy
What is the expression of how much drug is needed to produce a biological response. It describes
the difference in concentration or dosage of different drugs required to produce a similar effect.
, Drugs that are more potent require a lower dosage or concentration to produce the same
response. Relative potency
What is an exaggerated immune response? Allergy
What percentage of people with a PCN allergy will lose that allergy? 90%
What is an IgE mediated, immediate hypersensitivity? Type 1 allergic reaction
Does a type I reaction occur with the first dosage of the drug? No
What is an example of a type 1 allergic response? Angioedema, anaphylaxis
What 2 body systems will you normally see with type I reactions? Respiratory,
circulatory
What is the drug of choice for type I allergic response? epinephrine
Solutions
What is a pharmacologically inactive medication that are metabolized into the active form within
the body? Pro drug
Ultra-rapid metabolizer (Explain ultra-rapid metabolizers. How do these differ from poor to
intermediate metabolizers?) prodrugs are rapidly metabolized into active drug. Active
drug is rapidly metabolized into inactive metabolite leading to potential therapeutic failure.
Patient requires higher doses of active drug.
What is it when a person has more than one functioning copy of a certain enzyme and metabolize
drugs at a very fast rate? Ultra rapid metabolizer
What inactivates the drug and less will reach the system? Hepatic first-pass
What helps determine the safety of a drug? Half-life
What is it when 50% of the original drug is in the body? Half-life (dosing intervals)
,What is elimination of the drug metabolite in the body? Excretion
What are ways drugs are excreted out of the body? (1) renal (2) saliva (3) skin (4) breast
milk
What is the relationship between a drug's desired therapeutic effects and adverse effects?
Therapeutic drug level
Are lipid soluble drugs easily excreted from the body? No
What is the goal with lipid soluble drugs so that they can be excreted from the body?
Make more water soluble
What is the maximum effect a drug can produce at any dosage? Maximal efficacy
What is the expression of how much drug is needed to produce a biological response. It describes
the difference in concentration or dosage of different drugs required to produce a similar effect.
, Drugs that are more potent require a lower dosage or concentration to produce the same
response. Relative potency
What is an exaggerated immune response? Allergy
What percentage of people with a PCN allergy will lose that allergy? 90%
What is an IgE mediated, immediate hypersensitivity? Type 1 allergic reaction
Does a type I reaction occur with the first dosage of the drug? No
What is an example of a type 1 allergic response? Angioedema, anaphylaxis
What 2 body systems will you normally see with type I reactions? Respiratory,
circulatory
What is the drug of choice for type I allergic response? epinephrine
