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UWorld & NBME Practice Tests Question and Answer
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25
May 2023
2022/2023
A+
Fetal hydantoin syndrome - D/t use of phenytoin or other anti-epileptic (*valproic acid, carbamazepine*), which can cross the placenta, generating *low folate* and high oxidative metabolites.
Results in *cleft lip and palate, wide anterior fontanelle, distal phalange hypoplasia, cardiac anomalies, neural tube defects, microcephaly*, causing developmental delay and poor cognitive outcomes.
Of these risks, *neural tube defects* is the *greatest*.
Fetal alcohol syndrome - Can present w/ mi...
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