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TNFerade, an Adenovector Carrying the Transgene for Human Tumor Necrosis Factor a, for Patients With Advanced Solid Tumors: Surgical Experience and Long-Term Follow-Up
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6

July 2024

2023/2024

A+
In 1975, Carswell et al.1 first identified tumor necrosis factor (TNF)-a as a cytokine involved in tumor necrosis. Since then, multiple studies have been performed to uncover the extent of its function and potential uses in human tumors. It has now been elucidated that TNF-a is a multifunctional, potent, tumoricidal cytokine released by macrophages.2–5 TNF-a can induce tumor cell death by several mechanisms. First, TNF-a binds to a number of possible receptors that activate a cascade...
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