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Exam (elaborations)
The Th17 lineage: Answers to some immunological questions
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---14August 20242024/2025A+
- CLUES TO THE IDENTIFICATION OF A NEW T 
HELPER CELL LINEAGE PRODUCING IL-17 
The first suggestion of a new T helper subset, distinct 
from Th1 and Th2, was provided by the finding of T CD4+ 
cells producing high levels of IL-17 without expression of 
IFN-γ or IL-4, the respective prototype cytokines produced 
by Th1 and Th2(19). Other important clues were supplied 
by studies on animal models of autoimmunity. Pathologies 
such as experimental autoimmune encephalomyelitis (EAE) 
and collagen-ind...
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