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The Th17 lineage:  Answers to some immunological questions
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    The Th17 lineage: Answers to some immunological questions

  • CLUES TO THE IDENTIFICATION OF A NEW T HELPER CELL LINEAGE PRODUCING IL-17 The first suggestion of a new T helper subset, distinct from Th1 and Th2, was provided by the finding of T CD4+ cells producing high levels of IL-17 without expression of IFN-γ or IL-4, the respective prototype cytokines produced by Th1 and Th2(19). Other important clues were supplied by studies on animal models of autoimmunity. Pathologies such as experimental autoimmune encephalomyelitis (EAE) and collagen-ind...
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