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p53 alterations in human cancer: more questions than answers
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12
August 2024
2024/2025
A+
The spectrum of p53 mutations is not a strong argument
to infer neomorphic or antimorphic mutations
Unlike most other tumour suppressor genes that are
inactivated by frameshift or nonsense mutations leading
to disappearance or aberrant synthesis of the gene
product, almost 80% of p53 gene mutations are missense
mutations leading to the synthesis of a stable protein,
lacking its specific DNA-binding activity and accumulating in the nucleus of tumour cells (Soussi, 2005).
Whether this hig...
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