- Study guides, Class notes & Summaries

Respiratory Depression - The most serious adverse effect of opioids, primarily through activation of mu receptors, with onset varying by route of administration. Equianalgesic Doses - Doses of different drugs or forms of the same drug that provide equivalent analgesic effects. Death Following Overdose - Almost always from respiratory arrest in cases of opioid overdose. Tolerance to Respiratory Depression - Develops with prolonged opioid use, where individuals require higher doses for the...