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The multidrug transporter ABCG2: still more questions than answers
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7
August 2024
2024/2025
A+
Topology and functionally important residues of ABCG2
A monomer of ABCG2 consists of a 655 amino acid protein with a 250 amino acid intracellular N-terminal NBD, an
uncharacterized linker region followed by six TMDs and associated intra and extracellular loops. Orange colours indicate
where the experimental and predicted topology differ. A number of residues have been identified as significant including
glycosylation site (green), stability affecting sites (red) and putative drug binding sit...
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