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Individual detection of 14 high risk human papilloma virus genotypes by the PapType test for the prediction of high grade cervical lesions Jack Cuzick∗ , Linda Ho, George Terry, Michelle Kleeman, Michael Giddings, Janet Austin, Louise Cadman, Lesley Ashdo
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6

July 2024

2023/2024

A+
. Background Over 230 distinct papillomavirus genotypes have been identified based on nucleic acid sequence analysis and 179 are human papillomaviruses [1,2]. 12–14 HR HPV genotypes are usually assayed collectively to achieve high sensitivity for predicting high grade cervical lesions. However, this leads to a low specificity, especially in young women [3–5]. As a result, individual genotype detection (in particular HPV16 and HPV18), has been added to some commercial tests and algori...
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