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Discordant human T-lymphotropic virus screening with Western blot confirmation: evaluation of the dual-test algorithm for US blood donations
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3

July 2024

2023/2024

A+
S creening for human T-lymphotropic virus (HTLV) antibodies in the United States was mandated by the Food and Drug Administration (FDA) in 1988 (first for HTLV-1 followed by HTLV-2 in 1998).1 In the United States, HTLV prevalence is relatively low at 3.37 per 100,000 donations collected from 2011 to 2012.2 HTLV screening has used a dual-testing algorithm beginning with either a chemiluminescent immunoassay or an enzyme-linked immunosorbent screening assay (ELISA). Before the availabil...
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