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A novel permutation test for case-only analysis identifies epistatic effects on human longevity in the FOXO gene family
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11

July 2024

2023/2024

A+
Complex diseases or phenotypes like longevity may have multiple genetic and environmental causes. The complexity arises from the fact that many genetic and environmental factors may interact with each other such that the expression of the phenotype may not be accurately predictable based on knowledge of the individual effects for each of the component factors considered alone. Genetic interactions or epistasis could hold the key to understanding of complex conditions such as Alzheimer’s d...
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