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Test of the Binding Threshold Hypothesis for olfactory receptors: Explanation of the differential binding of ketones to the mouse and human orthologs of olfactory receptor 912-93
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8

July 2024

2023/2024

A+
There continues to be uncertainty as to what aspect of an odorant is detected by an olfactory receptor (OR). Early models assumed that the shape of the odorant was most important (Amoore 1952). Experimental results reported by Buck and Axel (1991) showed that each OR recognizes several odors and each odor is recognized by several ORs. This raises the issue of what aspects of the molecule can provide this selectivity. Turin (1996) made the novel proposal that ORs detect the intramolecular...
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