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Exam (elaborations)
Alterations in Cardiovascular Function and Perfusion 2025-2026
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---20August 20252025/2026A+
- Anatomy & Physiology 
The Apex of the heart, or point of maximum impulse (PMI), is located at the fifth 
Intercostal space at the midclavicular line onthe left. 
Heart is composed of 3 layers: 
•	Endocardium – inner most layer. 
Endothelial tissue that lines heart and valves. 
•	Myocardium – middle layer. Muscle fibers & thickets layer of heart. • Epicardium – outer layer. Serous layer that protects the heart.Alterations in Cardiovascular Function and Perfusion
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TUTORNELSON