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Aire’s partnerships: An answer for many questions and new questions in search of answers
Aire’s partnerships
Aire’s partnerships
The focus of this perspective is the recent publication by Abramson etal. (1) on the role of the Aire (Autoimmune Regulator), which is a transcription factor involved in promoting the surveillance of self antigens and the maintenance of immune tolerance. This protein is mainly expressed in the medulla of the thymus and is important in the prevention of autoimmune disease including Type 1 diabetes (T1D). In humans, a defective AIRE causes Polyglandular Autoimmune Syndrome (APS) t...
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