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A Protein-Conjugate Approach to Develop a Monoclonal Antibody-Based Antigen Detection Test for the Diagnosis of Human Brucellosis
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13

August 2024

2024/2025

A+
Human brucellosis is most commonly caused by two species of the genus Brucella, typically B. abortus from cattle and B. melitensis from goats and sheep. The definitive diagnosis of brucellosis rests upon demonstration of the causative bacterium in a suspected patient’s body fluid, typically by culture isolation [1,2]. While detection of Brucella nucleic acids [3–13] or antigens [14] would be expected to be diagnostic for new cases of brucellosis, DNA has been reported to persist in bl...
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