PHARM NURS210
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Pharm Exam 4 2024 complete update A+ graded study guide 
 
 
 
 
 
 
 
 
 
 
MOA acetaminophen	- not clear 
- weak COX1/COX2 inhibitor 
- activation of descending serotonergic inhibitory pathways 
- antipyretic effects via inhibitory effects on hypothalamic "thermostat" 
 
adverse effects tylenol	- skin rash/allergy 
- hemolytic uremia 
- methemoglobinemia 
- hepatotoxicity (>4g/day, >15g lethal) 
 
early signs hepatotoxicity tylenol	nausea, vomiting, diarrhea, abdominal pain, dizzine...
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