NRNP 6566
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Latest content NRNP 6566
NRNP 6566 final prep 6-12 
Normal pH 
7.35-7.45 
 
<7.35 Acid 
>7.45 alkalosis 
respiratory aklalosis 
pH> 7.45, PaC02 low, HC03 low 
respiratory acidosis 
pH < 7.35 
PaCO2 > 45 
Hc03 normal 22-26 
Metabolic alkalosis 
pH > 7.45 
HCO3 > 26 
PaC02 45-35 
normal oxygen levle 
80-100 
mild hypoxemia 
60-80 
moderate hypoxemia 
40-60 
severe hypoxemia 
<40 
A-a gradiatian calculation is a calculation of what? 
level of hypoxia 
PA02-Pa02 
A-a gradiant varies with age, calcula...
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NRNP 6566 final prep 6-12 
Normal pH 
7.35-7.45 
 
<7.35 Acid 
>7.45 alkalosis 
respiratory aklalosis 
pH> 7.45, PaC02 low, HC03 low 
respiratory acidosis 
pH < 7.35 
PaCO2 > 45 
Hc03 normal 22-26 
Metabolic alkalosis 
pH > 7.45 
HCO3 > 26 
PaC02 45-35 
normal oxygen levle 
80-100 
mild hypoxemia 
60-80 
moderate hypoxemia 
40-60 
severe hypoxemia 
<40 
A-a gradiatian calculation is a calculation of what? 
level of hypoxia 
PA02-Pa02 
A-a gradiant varies with age, calcula...
NRNP 6566 
Mid-term Study Guide Week 1 to 5 
Week 1 
1. Describe the cytochrome P450 system. Describe how inducers and inhibitors affect the cytochrome system and how that affects the half-life of medications. 
Cytochromes P450 (CYPs) are a superfamily of enzymes containing heme as a cofactor that function as monooxygenases. In mammals, these proteins oxidize steroids, fatty acids, and xenobiotics, and are important for the clearance of various compounds, as well as for hormone synthesis and br...
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NRNP 6566 
Mid-term Study Guide Week 1 to 5 
Week 1 
1. Describe the cytochrome P450 system. Describe how inducers and inhibitors affect the cytochrome system and how that affects the half-life of medications. 
Cytochromes P450 (CYPs) are a superfamily of enzymes containing heme as a cofactor that function as monooxygenases. In mammals, these proteins oxidize steroids, fatty acids, and xenobiotics, and are important for the clearance of various compounds, as well as for hormone synthesis and br...
NRNP 6566 Knowledge Check Week 3 
 
Amiodarone has possible complex interactions with multiple medications. It has an effect on warfarin metabolism. Amiodarone is a potent inhibitor of cytochrome P450 enzymes and inhibition of these enzymes will cause an increased plasma concentration and decreased clearance; thereby increasing the prothrombin time and INR placing the patient at increased risk for bleeding complications. Hence, when given 
together, warfarin dose should be decreased and frequent...
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NRNP 6566 Knowledge Check Week 3 
 
Amiodarone has possible complex interactions with multiple medications. It has an effect on warfarin metabolism. Amiodarone is a potent inhibitor of cytochrome P450 enzymes and inhibition of these enzymes will cause an increased plasma concentration and decreased clearance; thereby increasing the prothrombin time and INR placing the patient at increased risk for bleeding complications. Hence, when given 
together, warfarin dose should be decreased and frequent...
•	 
NRNP 6566 Week 4 knowledge check 
 
 
 
 
A 47 year old male admitted with an infected elbow wound. On his second day in the hospital you find him in his room confused and agitated. 
 
Vital signs are as follows: 
Temperature – 96.2 °F 
Pulse -140 beats per minute Respirations – 40 breaths per minute Blood Pressure – 90/40 mmHg 
Labs include a WBC count of 3,000 Pt weighs 185 pounds 
Further assessment of him includes: 
 
Urine output of 100cc for the last 8 hours Pulse oximetry of...
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NRNP 6566 Week 4 knowledge check 
 
 
 
 
A 47 year old male admitted with an infected elbow wound. On his second day in the hospital you find him in his room confused and agitated. 
 
Vital signs are as follows: 
Temperature – 96.2 °F 
Pulse -140 beats per minute Respirations – 40 breaths per minute Blood Pressure – 90/40 mmHg 
Labs include a WBC count of 3,000 Pt weighs 185 pounds 
Further assessment of him includes: 
 
Urine output of 100cc for the last 8 hours Pulse oximetry of...
NRNP 6566 Week 5 Knowledge Check 
 
QUESTION 1 
1.	A 54-year women is 3 days post abdominal surgery for removal of a cancerous mass in her abdomen. She develops acute shortness of breath associated with tachycardia and hypotension. CT Scan of the chest is positive for multiple small pulmonary embolism. What medication and dosing would you order initially to treat the pulmonary embolism? 
 
This patient should be given fondaparinuc (Arixtra) subcutaneously. Dosing is weight- based: 
1.	5 mg SQ on...
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NRNP 6566 Week 5 Knowledge Check 
 
QUESTION 1 
1.	A 54-year women is 3 days post abdominal surgery for removal of a cancerous mass in her abdomen. She develops acute shortness of breath associated with tachycardia and hypotension. CT Scan of the chest is positive for multiple small pulmonary embolism. What medication and dosing would you order initially to treat the pulmonary embolism? 
 
This patient should be given fondaparinuc (Arixtra) subcutaneously. Dosing is weight- based: 
1.	5 mg SQ on...
•	 
NRNP 6566 week 6 knowledge check. 
 
 
 
 
A 54 year old female has a 30 year pack smoking history. She recently underwent pulmonary function testing which showed moderate obstructive lung disease. What would your treatment plan (including medications) include for this patient? 
 
 
Correct 
Answer: The Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2020 suggests that smoking cessation should be immediately pursued if the patient is still smoking. Nicotine replacement (gum,...
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NRNP 6566 week 6 knowledge check. 
 
 
 
 
A 54 year old female has a 30 year pack smoking history. She recently underwent pulmonary function testing which showed moderate obstructive lung disease. What would your treatment plan (including medications) include for this patient? 
 
 
Correct 
Answer: The Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2020 suggests that smoking cessation should be immediately pursued if the patient is still smoking. Nicotine replacement (gum,...
•	 
NRNP 6566 Week 7 knowledge check 
 
 
•	Question 1 
 
A patient with respiratory failure has hemodynamic monitoring and is receiving mechanical ventilation with peak end-expiratory pressure (PEEP) of 10 cm H2O. Which information indicates that a change in the ventilator settings may be required? 
a.	The arterial line shows a blood pressure of 90/46. 
b.	The pulmonary artery pressure (PAP) is decreased. 
c.	The cardiac monitor shows a heart rate of 58 beats/min. 
d.	The pulmonary artery ...
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NRNP 6566 Week 7 knowledge check 
 
 
•	Question 1 
 
A patient with respiratory failure has hemodynamic monitoring and is receiving mechanical ventilation with peak end-expiratory pressure (PEEP) of 10 cm H2O. Which information indicates that a change in the ventilator settings may be required? 
a.	The arterial line shows a blood pressure of 90/46. 
b.	The pulmonary artery pressure (PAP) is decreased. 
c.	The cardiac monitor shows a heart rate of 58 beats/min. 
d.	The pulmonary artery ...
•	 
NRNP 6566 Week 8 Knowledge check 
 
 
 
 
What type of ICU sedation would be appropriate for a 32 year old male patient who is intubated with bilateral chest tube following a motor vehicle crash. 
 
 
Correct 
Answer: The Society of Critical Care Medicine publishes a guideline on sedation. It is: Guidelines for the Prevention and Management of Pain, Agitation/Sedation, Delirium, Immobility, and Sleep Disruption in Adult Patients in the ICU 
(2018). 
Light sedation is suggested for intubat...
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NRNP 6566 Week 8 Knowledge check 
 
 
 
 
What type of ICU sedation would be appropriate for a 32 year old male patient who is intubated with bilateral chest tube following a motor vehicle crash. 
 
 
Correct 
Answer: The Society of Critical Care Medicine publishes a guideline on sedation. It is: Guidelines for the Prevention and Management of Pain, Agitation/Sedation, Delirium, Immobility, and Sleep Disruption in Adult Patients in the ICU 
(2018). 
Light sedation is suggested for intubat...
•	 
NRNP 6566 week 9 knowledge check 
 
 
 
 
A 32 year old preschool teacher complains of difficulty swallowing, sore throat, and chills. She is febrile with a temperature of 101.6 along with white patches on her tonsils. Her rapid strep test is positive. Her past medical history is positive for an anaphylactic reaction to cefaclor two years ago. What antibiotic could be safely utilized in this patient? 
 
 
Correct 
Answer: Streptococcus is usually treated with amoxicillin. Her type 1 anaph...
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NRNP 6566 week 9 knowledge check 
 
 
 
 
A 32 year old preschool teacher complains of difficulty swallowing, sore throat, and chills. She is febrile with a temperature of 101.6 along with white patches on her tonsils. Her rapid strep test is positive. Her past medical history is positive for an anaphylactic reaction to cefaclor two years ago. What antibiotic could be safely utilized in this patient? 
 
 
Correct 
Answer: Streptococcus is usually treated with amoxicillin. Her type 1 anaph...
•	 
NRNP 6566 week 11 knowledge check 
 
 
 
 
How would you differentiate between diabetic ketoacidosis (DKA) and hyperosmolar hyperglycemic syndrome (HHS)? 
 
 
Correct 
Answer: Both of these conditions will include high levels of blood glucose readings. DKA will exhibit acidosis and urinary ketones while HHS will not. Treatment for each condition is similar with fluid bolus and infusion as well as insulin 
bolus and infusion. 
Juan is a 42 year old male with complaints of nausea and vomiti...
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NRNP 6566 week 11 knowledge check 
 
 
 
 
How would you differentiate between diabetic ketoacidosis (DKA) and hyperosmolar hyperglycemic syndrome (HHS)? 
 
 
Correct 
Answer: Both of these conditions will include high levels of blood glucose readings. DKA will exhibit acidosis and urinary ketones while HHS will not. Treatment for each condition is similar with fluid bolus and infusion as well as insulin 
bolus and infusion. 
Juan is a 42 year old male with complaints of nausea and vomiti...