Certified Anticoagulation Care Provider (CACP)
practice exam Verified Questions, Correct
Answers, and Detailed Explanations for Science
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1. Which clotting factors are inhibited by warfarin?
A. Factors I, II, V, VIII
B. Factors II, VII, IX, X
C. Factors IX, X, XI, XII
D. Factors I, III, V, VIII
Answer: B
Warfarin inhibits vitamin K–dependent clotting factors II, VII, IX, and X.
2. The primary laboratory test used to monitor warfarin therapy is:
A. aPTT
B. INR
C. Platelet count
D. Anti-Xa level
Answer: B
The INR standardizes PT results to assess warfarin anticoagulation intensity.
3. What is the usual target INR for treatment of nonvalvular atrial
fibrillation?
A. 1.5–2.0
B. 2.0–3.0
C. 2.5–3.5
D. 3.0–4.0
Answer: B
Most AF patients require a target INR of 2.0–3.0 to balance stroke prevention
and bleeding risk.
,4. Which direct oral anticoagulant (DOAC) is a direct thrombin inhibitor?
A. Apixaban
B. Edoxaban
C. Dabigatran
D. Rivaroxaban
Answer: C
Dabigatran directly inhibits thrombin (factor IIa).
5. Which DOAC requires twice-daily dosing?
A. Rivaroxaban
B. Edoxaban
C. Apixaban
D. Betrixaban
Answer: C
Apixaban is administered twice daily for most indications.
6. Which medication is used as a reversal agent for warfarin?
A. Protamine sulfate
B. Idarucizumab
C. Vitamin K
D. Andexanet alfa
Answer: C
Vitamin K reverses warfarin’s inhibition of clotting factor synthesis.
7. What is the mechanism of action of unfractionated heparin?
A. Direct factor Xa inhibition
B. Antithrombin-mediated inhibition of IIa and Xa
C. Vitamin K antagonism
D. Platelet inhibition
Answer: B
Heparin enhances antithrombin’s inhibition of thrombin and factor Xa.
, 8. Which lab test is primarily used to monitor unfractionated heparin?
A. INR
B. Anti-Xa (routine)
C. aPTT
D. Platelet count
Answer: C
aPTT reflects the anticoagulant effect of unfractionated heparin.
9. Low-molecular-weight heparins primarily inhibit:
A. Thrombin only
B. Factor Xa more than thrombin
C. Vitamin K–dependent factors
D. Platelet aggregation
Answer: B
LMWHs have greater activity against factor Xa than thrombin.
10. Which condition is an absolute contraindication to anticoagulation?
A. History of falls
B. Controlled hypertension
C. Active major bleeding
D. Age >75 years
Answer: C
Active major bleeding is an absolute contraindication to anticoagulation
therapy.
11. Which score estimates stroke risk in atrial fibrillation?
A. HAS-BLED
B. CHA₂DS₂-VASc
C. Wells score
D. TIMI score
practice exam Verified Questions, Correct
Answers, and Detailed Explanations for Science
Students||Already Graded A+
1. Which clotting factors are inhibited by warfarin?
A. Factors I, II, V, VIII
B. Factors II, VII, IX, X
C. Factors IX, X, XI, XII
D. Factors I, III, V, VIII
Answer: B
Warfarin inhibits vitamin K–dependent clotting factors II, VII, IX, and X.
2. The primary laboratory test used to monitor warfarin therapy is:
A. aPTT
B. INR
C. Platelet count
D. Anti-Xa level
Answer: B
The INR standardizes PT results to assess warfarin anticoagulation intensity.
3. What is the usual target INR for treatment of nonvalvular atrial
fibrillation?
A. 1.5–2.0
B. 2.0–3.0
C. 2.5–3.5
D. 3.0–4.0
Answer: B
Most AF patients require a target INR of 2.0–3.0 to balance stroke prevention
and bleeding risk.
,4. Which direct oral anticoagulant (DOAC) is a direct thrombin inhibitor?
A. Apixaban
B. Edoxaban
C. Dabigatran
D. Rivaroxaban
Answer: C
Dabigatran directly inhibits thrombin (factor IIa).
5. Which DOAC requires twice-daily dosing?
A. Rivaroxaban
B. Edoxaban
C. Apixaban
D. Betrixaban
Answer: C
Apixaban is administered twice daily for most indications.
6. Which medication is used as a reversal agent for warfarin?
A. Protamine sulfate
B. Idarucizumab
C. Vitamin K
D. Andexanet alfa
Answer: C
Vitamin K reverses warfarin’s inhibition of clotting factor synthesis.
7. What is the mechanism of action of unfractionated heparin?
A. Direct factor Xa inhibition
B. Antithrombin-mediated inhibition of IIa and Xa
C. Vitamin K antagonism
D. Platelet inhibition
Answer: B
Heparin enhances antithrombin’s inhibition of thrombin and factor Xa.
, 8. Which lab test is primarily used to monitor unfractionated heparin?
A. INR
B. Anti-Xa (routine)
C. aPTT
D. Platelet count
Answer: C
aPTT reflects the anticoagulant effect of unfractionated heparin.
9. Low-molecular-weight heparins primarily inhibit:
A. Thrombin only
B. Factor Xa more than thrombin
C. Vitamin K–dependent factors
D. Platelet aggregation
Answer: B
LMWHs have greater activity against factor Xa than thrombin.
10. Which condition is an absolute contraindication to anticoagulation?
A. History of falls
B. Controlled hypertension
C. Active major bleeding
D. Age >75 years
Answer: C
Active major bleeding is an absolute contraindication to anticoagulation
therapy.
11. Which score estimates stroke risk in atrial fibrillation?
A. HAS-BLED
B. CHA₂DS₂-VASc
C. Wells score
D. TIMI score
