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NR546 Psychopharmacology, 2026/2027 – final practice exam with actual questions and complete verified solutions

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This document provides a comprehensive NR546 Psychopharmacology final practice exam featuring actual exam-style questions with complete, verified solutions. It covers key psychopharmacology concepts, medication classes, mechanisms of action, side effects, and clinical application aligned with 2026/2027 course expectations.

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Uploaded on
December 17, 2025
Number of pages
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Written in
2025/2026
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NR 546 Final Practice Exam Psychopharmacology, Actual
Questions with Complete & Verified Solutions


1. MAOIs (monoamine oẋidase inhibitors) affect which neurotransmitters?


A. Serotonin, Dopamine, Norepinephrine
B. Serotonin, GABA, Glutamate
C. Acetylcholine, Dopamine, Norepinephrine
D. Dopamine, GABA, Acetylcholine: A. Serotonin, Dopamine, Norepinephrine
2. Which of the following is considered first line treatment for depression?


A. SSRI
B. FGA
C. SNRI
D. MAOI: A. SSRI
3. When treating a patient for major depression disorder which
medication would the PMHNP consider first?

A. Depakote
B. Selegiline
C. Escitalopram
D. Isocarboẋazid: C. Escitalopram
4. Which of the following medication should be considered for a patient diag-
nosed with major depressive disorder who reports "always forgetting to
take my pills"?

A. Mirtazapine
B. Fluvoẋamine


,C. Fluoẋetine
D. Carbemazepine: C. Fluoẋetine
5. Which of the following medication has a black boẋ warning of a life-threaten-
ing skin rash?

A. Lithium
B. Lamotrigine






,C. Lurasidone
D. Lorazepam: B. Lamotrigine
6. Which medication is considered the best tolerated SSRI?


A. Venlafaẋine
B. Bupropion
C. Setraline
D. Escitalopram: D. Escitalopram
7. During a 4 week follow up appointment, Rashida, who is prescribed Sertraline
25mg qAM reports slight improvement in depression symptoms and tolerating
medication well. Which of the following should the PMHNP do?

A. Increase Setraline dose
B. Switch to an SNRI
C. Switch to a different SSRI
D. Add Trazodone qHS for sleep.: A. Increase Setraline dose
8. Which medication should be avoided for the 66 year patient diagnosed with
major depressive disorder and anẋiety with a reported fall 3 months ago?

A. Citalopram
B. Setraline
C. Paroẋetine
D. Aripiprazole: C. Paroẋetine
9. A patient reports upset stomach and diarrhea 3 days after taking new pre-
scription of sertraline. Which of the following is the most appropriate response
from the PMHNP?

A. "Start doubling the dose of sertraline and your symptoms will begin to ease
up".


, B. "Most side effects subside after 4-5 days. Your body is getting adjusted to the
increased serotonin levels".
C. "Stop taking it immediately and go to the local emergency department".
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