Which of the following would you most expect to be an exclusioncriterion for a
clinical trial for a new therapy for pediatric leukemia?
Patient is male
Patient is Hispanic
Patient has leukemia
Patient is greater than 12 years old
Give this one a try later!
Patient is greater than 12 years old
Which of the following are OTC drugs in the U.S.? Select all that apply.
Codeine
Diphenhydramine
Loperamide
,levothyroxine
6-tert-butyl-3-(4,5-dihydro-1H-imidazol-2-ylmethyl)-2,4-
dimethylphenol;hydrochloride
Tadalafil
Give this one a try later!
Diphenhydramine
Loperamide
6-tert-butyl-3-(4,5-dihydro-1H-imidazol-2-ylmethyl)-2,4-
dimethylphenol;hydrochloride
How many groups of patients would be required for a placebo-controlled factorial
trial to test combinations of three drugs?
3
5
6
7
8
Give this one a try later!
8
Imagine a drug with kEL = 1.2 hr-1, clearance = 14.4 L/hr, and VD = 12 L/kg. In order to
achieve a steady-state plasma concentration of 2 mg/L, how large should each
maintenance dose be if a 30 kg patient is going to take an oral dose every 12 hours.
Assume 100% bioavailability and first-order metabolism.
,28 mg
173 mg
346 mg
720 mg
864 mg
Give this one a try later!
346 mg
Genetic changes may lead to which of the following (choose none, some, or all).
Increased sensitivity of CML to Gleevec
Decreased sensitivity of CML to Gleevec
Give this one a try later!
Increased sensitivity of CML to Gleevec
Decreased sensitivity of CML to Gleevec
Which type of response curve would you look at if you wanted to know the exact
response predicted in a controlled system at a specified drug concentration?
Graded concentration response
Quantal dose response
Give this one a try later!
Graded concentration response
, Genetics can influence which of the following (choose none, some, or all).
Pharmacokinetics
Pharmacodynamics
Give this one a try later!
Pharmacokinetics
Pharmacodynamics
A tuberculosis patient is not responding to isoniazid treatment. The physician takes a
DNA sample from the patient and sends it for testing. What gene is she likely having
genotyped?
P450
methyl transferase
sulfo transferase
N-acetyl transferase
SecF, a membrane protein in M. tuberculosis
Give this one a try later!
N-acetyl transferase
A breast cancer patient is undergoing tamoxifen treatment. If she has a polymorphism
of CYP2D6 that leads to decreasedenzyme activity, which of the following is true?
She will be prescribed a lower dose of tamoxifen.
She will not be prescribed tamoxifen.
This will have no impact on her dose of tamoxifen.
clinical trial for a new therapy for pediatric leukemia?
Patient is male
Patient is Hispanic
Patient has leukemia
Patient is greater than 12 years old
Give this one a try later!
Patient is greater than 12 years old
Which of the following are OTC drugs in the U.S.? Select all that apply.
Codeine
Diphenhydramine
Loperamide
,levothyroxine
6-tert-butyl-3-(4,5-dihydro-1H-imidazol-2-ylmethyl)-2,4-
dimethylphenol;hydrochloride
Tadalafil
Give this one a try later!
Diphenhydramine
Loperamide
6-tert-butyl-3-(4,5-dihydro-1H-imidazol-2-ylmethyl)-2,4-
dimethylphenol;hydrochloride
How many groups of patients would be required for a placebo-controlled factorial
trial to test combinations of three drugs?
3
5
6
7
8
Give this one a try later!
8
Imagine a drug with kEL = 1.2 hr-1, clearance = 14.4 L/hr, and VD = 12 L/kg. In order to
achieve a steady-state plasma concentration of 2 mg/L, how large should each
maintenance dose be if a 30 kg patient is going to take an oral dose every 12 hours.
Assume 100% bioavailability and first-order metabolism.
,28 mg
173 mg
346 mg
720 mg
864 mg
Give this one a try later!
346 mg
Genetic changes may lead to which of the following (choose none, some, or all).
Increased sensitivity of CML to Gleevec
Decreased sensitivity of CML to Gleevec
Give this one a try later!
Increased sensitivity of CML to Gleevec
Decreased sensitivity of CML to Gleevec
Which type of response curve would you look at if you wanted to know the exact
response predicted in a controlled system at a specified drug concentration?
Graded concentration response
Quantal dose response
Give this one a try later!
Graded concentration response
, Genetics can influence which of the following (choose none, some, or all).
Pharmacokinetics
Pharmacodynamics
Give this one a try later!
Pharmacokinetics
Pharmacodynamics
A tuberculosis patient is not responding to isoniazid treatment. The physician takes a
DNA sample from the patient and sends it for testing. What gene is she likely having
genotyped?
P450
methyl transferase
sulfo transferase
N-acetyl transferase
SecF, a membrane protein in M. tuberculosis
Give this one a try later!
N-acetyl transferase
A breast cancer patient is undergoing tamoxifen treatment. If she has a polymorphism
of CYP2D6 that leads to decreasedenzyme activity, which of the following is true?
She will be prescribed a lower dose of tamoxifen.
She will not be prescribed tamoxifen.
This will have no impact on her dose of tamoxifen.
