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OMK18 – RAT 3 Prequiz | 100 Q&A | Immunodeficiencies, Hypersensitivity, Antibody Structure, MHC

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This document includes 100 detailed and exam-relevant questions with answers from OMK18 (Week 6 RAT 3 Prequiz) at a Medical University, specifically created for the 2025/2026 academic year. The focus lies in core immunological concepts such as adaptive immunity, antibody structure and function, immune tolerance, hypersensitivity types, and primary immunodeficiencies. It is ideal for assessments requiring conceptual understanding and diagnostic reasoning. Immunological themes include: Antibody structure and diversity: Roles of the Fab and Fc regions, heavy and light chains, variable and constant domains, isotype switching (IgM, IgG, IgA, IgE, IgD), and complementarity-determining regions (CDRs) for antigen recognition. V(D)J recombination and somatic hypermutation: Gene segment rearrangement, junctional diversity, affinity maturation, and enzyme functions (AID, RAG1/2, TdT). Major Histocompatibility Complex (MHC): Structure and function of MHC I vs MHC II, antigen processing pathways, and peptide loading for CD8+ and CD4+ T cells. Central and peripheral tolerance: Negative selection in thymus and bone marrow, role of AIRE, clonal deletion, and Treg-mediated suppression to prevent autoimmunity. Types I–IV hypersensitivity: Mechanisms and clinical examples—Type I (IgE-mediated allergy), Type II (cytotoxic), Type III (immune complex), and Type IV (delayed-type, T-cell mediated). Primary immunodeficiencies: SCID, DiGeorge syndrome, agammaglobulinemia, selective IgA deficiency, and Hyper-IgE syndrome (Job syndrome) with genetic and clinical features. Additional topics include: Class-switch recombination (CSR) and immunoglobulin gene expression Thymus structure, medulla vs cortex, and markers of maturing T cells CD markers and immunophenotyping: CD3, CD4, CD8, CD19, CD20, CD25 Autoimmunity and immune regulation: Self-tolerance mechanisms and breakdown Clinical cases and lab test interpretation for suspected immune disorders The content is structured to assist students in mastering both theoretical foundations and practical diagnostic applications in immunology, particularly for NBME-style exams and RAT assessments. Recommended for: Medical students (MD/MBBS) Pharmacy (PharmD) Biomedical Sciences Physician Associate (PA) Clinical Immunology & Pathology Nursing (BSc Nursing) Useful for courses like: Basic and Clinical Immunology Systems-Based Integrated Medicine (OMK or block curriculum) Pathophysiology of Immune Disorders Diagnostic Immunology Keywords: antibody structure, Fab region, Fc region, immunoglobulin classes, VDJ recombination, CDR regions, isotype switching, somatic hypermutation, MHC I, MHC II, antigen presentation, CD4 CD8, central tolerance, peripheral tolerance, AIRE gene, thymus selection, hypersensitivity types, SCID, DiGeorge syndrome, agammaglobulinemia, Hyper-IgE, T cell markers, immune checkpoints, immune tolerance failure, Treg cells

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OMK: PT6 Wk 19-20 (RAT/LO/PLOs)
2025/2026 Exam Questions and Correct
Answers | New Update



PLO: Explain the course of blood flow from the aorta back to the left

ventricle; learn the functions of the right and left atria and ventricles. (Dr.

Morganelli) - 🧠ANSWER ✔✔1.) Vena cava


2.) Left atrium

-----tricuspid valve----

3.) Left ventricle

----pulmonary valve---

4.) Pulmonary trunk/artery (a=away from heart)

,---lungs---

5.) pulmonary veins (there's 4)

6.) right atrium

----mitral valve---

7.) right ventricle

----aortic valve---

8.) aorta (ascending)

9.) Arch of right brachiocephalic, left carotid, left subclavian artery

---to the body---

PLO: Define systole and diastole; define stroke volume, end-diastolic

volume, end-systolic volume, and ejection fraction. - 🧠ANSWER

✔✔●Systole- period of ventricular contraction and ejection.




●Diastole- period of ventricular relaxation and filling




●Stroke volume (SV)- amount of blood ejected by ventricles per cardiac

cycle as a rate (60- 100 mls for adults)

,●End-systolic volume (ESV)- volume of blood in ventricles at END of

systole.




●End-diastolic volume (EDV)- volume of blood in ventricles at END of

diastole.




●Ejection fraction (EF)- EF = (SV/EDV)x 100; volume that is ejected out of

total ED volume as a percent; 55-75% for healthy adults.

PLO: Define cardiac output and learn the units that normally indicate it;

learn how SV and HR relate to CO. - 🧠ANSWER ✔✔Cardiac Output= total

output of the ventricles as a volume (L/min). Can change as our metabolic

needs change

-cardiac index= cardiac output rate/surface area (used on assessing CO on

babies)

● CO = (SV)(HR)




COPYRIGHT©JOSHCLAY 2025/2026. YEAR PUBLISHED 2025. COMPANY REGISTRATION NUMBER: 619652435. TERMS OF USE. PRIVACY
3
STATEMENT. ALL RIGHTS RESERVED

, *O=VR *think: ovaries

SV=stroke volume

*HR=heart rate

PLO: Define systemic or total vascular resistance (TRP) - 🧠ANSWER

✔✔=the resistance in the circulatory system that creates blood pressure.


-increase vasoconstriction, causes increases resistance




-Mean Arterial Pressure=drives the cardiac circulation, makes sense since

arteries does all the work pushing blood out

PLO: Define mean arterial pressure (MAP); learn the relationship between

MAP, CO, and TPR - 🧠ANSWER ✔✔=average pressure in the LARGE

arteries for a cardiac cycle and the force that maintains

flow

-main force that drives the cardiac circulation, makes sense since arteries

does all the work pushing blood out

●MAP at rest =diastolic P + 1/3 (sys-diastolic)

●MAP =CO x TPR

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