MGY 250 Unit 3 Quiz Questions with Verified Solutions Latest Update 2025/2026
Frameshift mutations:
Affect the codon with the SNV alone
Affect the codon with the SNV and all prior codons in the open reading frame
Affect the codon with the SNV and all subsequent codons in the open reading frame
Affect the codon with the SNV and the upstream region of the gene - Answers Affect the codon
with the SNV and all subsequent codons in the open reading frame
Nondisjunction at meiosis II leads to gametes that are (select all that apply):
Nullisomic (0 copies of a chromosome)
Trisomic (3 copies of a chromosome)
Monosomic (1 copy of a chromosome)
Disomic (2 copies of a chromosome) - Answers Nullisomic (0 copies of a chromosome)
Monosomic (1 copy of a chromosome)
Disomic (2 copies of a chromosome)
Select the following statements that are true:
Individuals with balanced translocations are usually phenotypically normal but may have a child
with a chromosomal structural abnormality
The Philadelphia chromosome found in CML is created by a duplication in the chromosome
harbouring BCR-ABL1 - Answers Individuals with balanced translocations are usually
phenotypically normal but may have a child with a chromosomal structural abnormality
Match the word with the definition:
Definitions:
The replacement of a nucleotide that results in a change in the amino acid coded for
, The replacement of a nucleotide that results in a stop codon
The insertion of a nucleotide in the DNA sequence
The deletion of a nucleotide in the DNA sequence
Word:
Synonymous mutation
Missense mutation
Nosense mutation
Frameshift mutation - Answers The replacement of a nucleotide that results in a change in the
amino acid coded for --> Missense mutation
The replacement of a nucleotide that results in a stop codon --> Nosense mutation
The insertion of a nucleotide in the DNA sequence --> Frameshift mutation
The deletion of a nucleotide in the DNA sequence --> Frameshift mutation
Mutations in the gene MOGEN cause it to interfere with the binding of wild-type (normal)
MOGEN to its target genes. This is an example of a:
Missense mutation
Dominant negative mutation
Frameshift mutation
Loss-of-function mutation - Answers Dominant negative mutation
A deletion of the last exon of a gene will likely have the same phenotype as a nonsense
mutation that results in a stop codon immediately prior to the last exon of a gene:
True
False - Answers True
The distinction between single nucleotide variants (SNVs) and single nucleotide polymorphisms
(SNPs) is:
Frameshift mutations:
Affect the codon with the SNV alone
Affect the codon with the SNV and all prior codons in the open reading frame
Affect the codon with the SNV and all subsequent codons in the open reading frame
Affect the codon with the SNV and the upstream region of the gene - Answers Affect the codon
with the SNV and all subsequent codons in the open reading frame
Nondisjunction at meiosis II leads to gametes that are (select all that apply):
Nullisomic (0 copies of a chromosome)
Trisomic (3 copies of a chromosome)
Monosomic (1 copy of a chromosome)
Disomic (2 copies of a chromosome) - Answers Nullisomic (0 copies of a chromosome)
Monosomic (1 copy of a chromosome)
Disomic (2 copies of a chromosome)
Select the following statements that are true:
Individuals with balanced translocations are usually phenotypically normal but may have a child
with a chromosomal structural abnormality
The Philadelphia chromosome found in CML is created by a duplication in the chromosome
harbouring BCR-ABL1 - Answers Individuals with balanced translocations are usually
phenotypically normal but may have a child with a chromosomal structural abnormality
Match the word with the definition:
Definitions:
The replacement of a nucleotide that results in a change in the amino acid coded for
, The replacement of a nucleotide that results in a stop codon
The insertion of a nucleotide in the DNA sequence
The deletion of a nucleotide in the DNA sequence
Word:
Synonymous mutation
Missense mutation
Nosense mutation
Frameshift mutation - Answers The replacement of a nucleotide that results in a change in the
amino acid coded for --> Missense mutation
The replacement of a nucleotide that results in a stop codon --> Nosense mutation
The insertion of a nucleotide in the DNA sequence --> Frameshift mutation
The deletion of a nucleotide in the DNA sequence --> Frameshift mutation
Mutations in the gene MOGEN cause it to interfere with the binding of wild-type (normal)
MOGEN to its target genes. This is an example of a:
Missense mutation
Dominant negative mutation
Frameshift mutation
Loss-of-function mutation - Answers Dominant negative mutation
A deletion of the last exon of a gene will likely have the same phenotype as a nonsense
mutation that results in a stop codon immediately prior to the last exon of a gene:
True
False - Answers True
The distinction between single nucleotide variants (SNVs) and single nucleotide polymorphisms
(SNPs) is:
