MGY 250 Unit 7 Quiz Questions with Verified Solutions Latest Update 2025/2026

MGY 250 Unit 7 Quiz Questions with Verified Solutions Latest Update 2025/2026 Which of the following are ways that tumours can be generated in mice (select all that apply): Inoculating an immunocompetent mouse with human tumour cells Genetically engineer a mouse with specific mutations to generate tumours Treat a mouse with carcinogens to generate tumours Inoculating an immunosuppressed mouse with human tumour cells - Answers Genetically engineer a mouse with specific mutations to generate tumours Treat a mouse with carcinogens to generate tumours Inoculating an immunosuppressed mouse with human tumour cells The policy of the American College of Medical Genetics and Genomics (ACMG) is to return information on 56 medically actionable genes from any clinical whole genome/exome sequencing endeavour. This is: Less information than the Canadian College of Medical Geneticists recommends providing More information than the Canadian College of Medical Geneticists recommends providing The same as the recommendations made by the Canadian College of Medical Geneticists - Answers More information than the Canadian College of Medical Geneticists recommends providing The term "secondary finding" has replaced "incidental finding" because: The finding is actively analyzed from genomic data, not passively stumbled upon They do not arise from an incident There was confusion as to whether incidental findings were primary findings The discovery can be made in seconds - Answers The finding is actively analyzed from genomic data, not passively stumbled upon There are two hotspot mutations in the enzyme PIK3CA that commonly occur in cancers like breast cancer. These mutations: Cause the enzyme PIK3CA to be locked in the "on" state, causing overproduction of the messenger protein PIP3 which promotes tumour growth and survival Are random and there is no knowledge of their function Cause the enzyme PIK3CA to be locked in the "off" state, causing suppression of the messenger molecule PIP3 which promotes tumour growth and survival Prevent the binding of a drug to inhibit PIK3CA function, which causes cancer - Answers Cause the enzyme PIK3CA to be locked in the "on" state, causing overproduction of the messenger protein PIP3 which promotes tumour growth and survival RB1 is a tumour suppressor gene and the RB pathway suppresses tumour growth. The RB pathway can be shut down by: Overexpression of RB1, or overexpression of an RB1 inhibitor like CDK4 or overexpression of the protein that regulates CDK4, CDKN2A Direct loss of function of RB1, or overexpression of an RB1 inhibitor like CDK4 or loss of function of the protein that regulates CDK4, CDKN2A Overexpression of RB1, or loss of function of an RB1 inhibitor like CDK4 or overexpression of the protein that regulates CDK4, CDKN2A Direct loss of function of RB1, or loss of function of an RB1 inhibitor like CDK4 or loss of function of the protein that regulates CDK4, CDKN2A - Answers Direct loss of function of RB1, or overexpression of an RB1 inhibitor like CDK4 or loss of function of the protein that regulates CDK4, CDKN2A In the Canada, the Genetic Non-discrimination Act (GNA, formerly known as Bill S-201) prevents discrimination from (select all that apply): Life insurance Disability insurance Employment insurance Family and social relationships - Answers Life insurance Disability insurance Employment insurance Bert Vogelstein showed that recurrent mutations in colon cancer: