Invisible sites where DNA synthesis begins. Many sites on each chromosome. To make
chromosome copies
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origins of replication
Found in birds, many snakes, moths, isopods, butterflies, amphibians, fishes. Female
ZW (heterogametic) Male ZZ (homogametic)
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ZZ-ZW Sex Determination
,Controlled mating is not possible
Long generation time: expect around 40 years to observe F2 generation
Family size is typically small
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Human Genetic Studies disadvantages
Females with a single X chromosome referred to as XO. Underdeveloped secondary
sex characteristics. Typically short, a low hairline, broad chest, folds of skin on the
neck. Intelligence is usually normal.
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Turner Syndrome
Double Helix structure of DNA discovered by Watson and Crick
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1950s
two eggs fertilized by two sperm from two men at about the same time (half-siblings)
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, Bi-paternal twins
MRNA to DNA
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Reverse Transcription
2 nearly identical chromosomes, inherited from parents
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Homologous Pair
Alleles at different loci separate independently of one another. Occurs in anaphase 1
of meiosis
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Principle of Independent Assortment (Mendel's second law)
Takes place over decades. In the fetus, primordial germ cells replicate DNA and pair
up homologous chromosomes for crossing over. Then meiosis arrests. In the adult,
oocyte (2n) resumes meiosis to segregate homologous chromosomes. Upon
, fertilization by sperm, the egg undergoes meiosis 2, segregating sister chromosomes
to become ovum (1n)
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Meiosis in Human Females
Full genome sequences determined: Bacteria, Yeast, Human, Animals, Plants
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Genomic Era (1995)
BB or Bb is a low risk (12%) of breast cancer, but bb is 60% risk. BRCA 1 phenotype is
not fully penetrant because you can be bb and still have non-cancerous cells in
breast.
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BRCA1 ex
Both sexes show similar frequencies. Tend to skip generations. heterozygote parents
do not show traits. May go several generations without appearance of the disease.
Penetrance and sex influence can complicate interpretation. ex. Tay-Sachs.
Homozygous recessive trait is most
frequent in mating between close
relatives -Consanguinity
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chromosome copies
Give this one a try later!
origins of replication
Found in birds, many snakes, moths, isopods, butterflies, amphibians, fishes. Female
ZW (heterogametic) Male ZZ (homogametic)
Give this one a try later!
ZZ-ZW Sex Determination
,Controlled mating is not possible
Long generation time: expect around 40 years to observe F2 generation
Family size is typically small
Give this one a try later!
Human Genetic Studies disadvantages
Females with a single X chromosome referred to as XO. Underdeveloped secondary
sex characteristics. Typically short, a low hairline, broad chest, folds of skin on the
neck. Intelligence is usually normal.
Give this one a try later!
Turner Syndrome
Double Helix structure of DNA discovered by Watson and Crick
Give this one a try later!
1950s
two eggs fertilized by two sperm from two men at about the same time (half-siblings)
Give this one a try later!
, Bi-paternal twins
MRNA to DNA
Give this one a try later!
Reverse Transcription
2 nearly identical chromosomes, inherited from parents
Give this one a try later!
Homologous Pair
Alleles at different loci separate independently of one another. Occurs in anaphase 1
of meiosis
Give this one a try later!
Principle of Independent Assortment (Mendel's second law)
Takes place over decades. In the fetus, primordial germ cells replicate DNA and pair
up homologous chromosomes for crossing over. Then meiosis arrests. In the adult,
oocyte (2n) resumes meiosis to segregate homologous chromosomes. Upon
, fertilization by sperm, the egg undergoes meiosis 2, segregating sister chromosomes
to become ovum (1n)
Give this one a try later!
Meiosis in Human Females
Full genome sequences determined: Bacteria, Yeast, Human, Animals, Plants
Give this one a try later!
Genomic Era (1995)
BB or Bb is a low risk (12%) of breast cancer, but bb is 60% risk. BRCA 1 phenotype is
not fully penetrant because you can be bb and still have non-cancerous cells in
breast.
Give this one a try later!
BRCA1 ex
Both sexes show similar frequencies. Tend to skip generations. heterozygote parents
do not show traits. May go several generations without appearance of the disease.
Penetrance and sex influence can complicate interpretation. ex. Tay-Sachs.
Homozygous recessive trait is most
frequent in mating between close
relatives -Consanguinity
Give this one a try later!