PCB3134 - Cell Structure and Function Exam 4- SCOTT
STAGG Part 1: Accurate Solutions For Every Question
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Terms in this set (241)
Myofibrils Each muscle fiber contains numerous...
each of which is divided along its length into repeating units
Sarcomeres
called
Each sarcomere contains bundles of... containing actin, troponin,
Thin filaments
and tropomyosin
Thick filaments containing myosin
The striated pattern of skeletal arrangement of thin and thick filaments in myofibrils gives rise to
muscle and the Observed
shortening of sarcomeres during
contraction
What are thick filaments Hundreds of molecules of myosin
primarily composed of?
How are the myosin molecules In opposite directions in the two halves of the filament
oriented in thick filaments?
The myosin is arranged in a staggered fashion.• Protruding heads
thick filaments of myosin molecules contact the adjacent thin filaments, forming
cross-bridges.
What do thin filaments Thick filaments
interdigitate with?
How many sets of thin filaments Two sets
are in each I band?
What proteins are contained in F-actin, tropomyosin, and troponin
thin filaments?
Where do thin filaments extend The A band
toward in the I band?
What is located on either side of Thin filaments
the Z line in the I band?
What is the function of Tropomyosin is a rodlike molecule that fits in the grooves of F-
tropomyosin in muscle actin and blocks myosin binding, moving to allow access.
contraction?
What are the components of Troponin is composed of three polypeptides: TnT, TnC, and TnI.
troponin?
How many troponin complexes One troponin complex associates with each tropomyosin.
associate with each
tropomyosin?
, What role do troponin and Together, they constitute a calcium-sensitive switch that activates
tropomyosin play in muscle contraction in striated muscle.
contraction?
What protein keeps actin α-actinin
filaments bundled into parallel
arrays?
What does CapZ do in muscle Maintains the attachment of the plus ends to the Z line and caps
filament organization? the actin in the thin filaments.
What is the role of Binds the minus ends of the filaments to maintain stability.
Tropomodulin in muscle
filaments?
What protein stabilizes the Nebulin
organization of thin filaments?
what protein attaches the thick Titin
filaments to the Z line?
Connects Z line to M line- Helps provide muscle elasticity Fun
Titin
fact: Titin is the largest single chain protein - 3.7megaDaltons
What model explains the muscle The sliding filament model
contraction?
According to the model, muscle Thin filaments sliding past thick filaments, with no change in
contraction is due to what? length or either
What happens to thin filaments Thin filaments slide into the spaces between adjacent thick
during muscle contraction? filaments, overlapping with them and narrowing the I band.
What determines the amount of The amount of force generated depends on the number of actin-
force generated during muscle binding domains that contact the thin filaments.
contraction?
What characterizes the regions The presence of transient cross-bridges.
of overlap between thin and
thick filaments?
What forms the cross-bridges in Links between the F-actin of thin filaments and myosin heads of
muscle contraction? thick filaments.
How do cross-bridges behave They form and dissociate rapidly.
during muscle contraction?
What is the result of cross- Shortening of sarcomeres and muscle fiber contraction.
bridge formation in muscle
fibers?
What is the initial configuration Myosin begins in a high-energy 'cocked' configuration containing
of myosin in the contraction an ADP and a Pi molecule.
cycle?
What triggers the The transition of myosin to a more tightly bound state triggers
conformational change in the conformational change, which involves the release of Pi.
myosin during muscle
contraction?
What is associated with the The power stroke, a movement that causes the thick filament to
conformational change in pull against the thin filament, is associated with the
myosin? conformational change.
What remains attached to the The myosin heavy chain.
thin filament during the
contraction cycle?
What is required for cross- A new ATP molecule must bind to the thin filament.
bridge disassociation in muscle
contraction?
What happens to the myosin It returns to a high-energy state and binds to the thin filament
head after ATP hydrolysis? closer to the Z line.
STAGG Part 1: Accurate Solutions For Every Question
Save
Students also studied
INBDE Orthodontics NBDE II Review - Prosthodontics Perio Study
201 terms 69 terms Teacher 78 terms
dong_lee82 Preview melissa_jarvis7 Preview Hunter_Charters
Terms in this set (241)
Myofibrils Each muscle fiber contains numerous...
each of which is divided along its length into repeating units
Sarcomeres
called
Each sarcomere contains bundles of... containing actin, troponin,
Thin filaments
and tropomyosin
Thick filaments containing myosin
The striated pattern of skeletal arrangement of thin and thick filaments in myofibrils gives rise to
muscle and the Observed
shortening of sarcomeres during
contraction
What are thick filaments Hundreds of molecules of myosin
primarily composed of?
How are the myosin molecules In opposite directions in the two halves of the filament
oriented in thick filaments?
The myosin is arranged in a staggered fashion.• Protruding heads
thick filaments of myosin molecules contact the adjacent thin filaments, forming
cross-bridges.
What do thin filaments Thick filaments
interdigitate with?
How many sets of thin filaments Two sets
are in each I band?
What proteins are contained in F-actin, tropomyosin, and troponin
thin filaments?
Where do thin filaments extend The A band
toward in the I band?
What is located on either side of Thin filaments
the Z line in the I band?
What is the function of Tropomyosin is a rodlike molecule that fits in the grooves of F-
tropomyosin in muscle actin and blocks myosin binding, moving to allow access.
contraction?
What are the components of Troponin is composed of three polypeptides: TnT, TnC, and TnI.
troponin?
How many troponin complexes One troponin complex associates with each tropomyosin.
associate with each
tropomyosin?
, What role do troponin and Together, they constitute a calcium-sensitive switch that activates
tropomyosin play in muscle contraction in striated muscle.
contraction?
What protein keeps actin α-actinin
filaments bundled into parallel
arrays?
What does CapZ do in muscle Maintains the attachment of the plus ends to the Z line and caps
filament organization? the actin in the thin filaments.
What is the role of Binds the minus ends of the filaments to maintain stability.
Tropomodulin in muscle
filaments?
What protein stabilizes the Nebulin
organization of thin filaments?
what protein attaches the thick Titin
filaments to the Z line?
Connects Z line to M line- Helps provide muscle elasticity Fun
Titin
fact: Titin is the largest single chain protein - 3.7megaDaltons
What model explains the muscle The sliding filament model
contraction?
According to the model, muscle Thin filaments sliding past thick filaments, with no change in
contraction is due to what? length or either
What happens to thin filaments Thin filaments slide into the spaces between adjacent thick
during muscle contraction? filaments, overlapping with them and narrowing the I band.
What determines the amount of The amount of force generated depends on the number of actin-
force generated during muscle binding domains that contact the thin filaments.
contraction?
What characterizes the regions The presence of transient cross-bridges.
of overlap between thin and
thick filaments?
What forms the cross-bridges in Links between the F-actin of thin filaments and myosin heads of
muscle contraction? thick filaments.
How do cross-bridges behave They form and dissociate rapidly.
during muscle contraction?
What is the result of cross- Shortening of sarcomeres and muscle fiber contraction.
bridge formation in muscle
fibers?
What is the initial configuration Myosin begins in a high-energy 'cocked' configuration containing
of myosin in the contraction an ADP and a Pi molecule.
cycle?
What triggers the The transition of myosin to a more tightly bound state triggers
conformational change in the conformational change, which involves the release of Pi.
myosin during muscle
contraction?
What is associated with the The power stroke, a movement that causes the thick filament to
conformational change in pull against the thin filament, is associated with the
myosin? conformational change.
What remains attached to the The myosin heavy chain.
thin filament during the
contraction cycle?
What is required for cross- A new ATP molecule must bind to the thin filament.
bridge disassociation in muscle
contraction?
What happens to the myosin It returns to a high-energy state and binds to the thin filament
head after ATP hydrolysis? closer to the Z line.
