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What does Bethanechol activate - CORRECT ANSWER- muscarinic receptors (direct
acting muscarinic agonist)
The muscarinic agonists bind to muscarinic receptors and thereby cause receptor
activation. Because nearly all muscarinic receptors are associated with the
parasympathetic nervous system, responses to muscarinic agonists closely
resemble those produced by stimulation of parasympathetic nerves.
What is the action of bethanechol - CORRECT ANSWER- binds reversibly to muscarinic
cholinergic receptors to cause activation.
What are the principle structures affected by bethanechol - CORRECT ANSWER-
heart, exocrine glands, smooth muscles, and eyes
How does bethanechol affect the heart - CORRECT ANSWER- Muscarinic agonists act
on the heart to cause bradycardia (decreased heart rate)
,How does bethanechol act on sweat glands? - CORRECT ANSWER- exocrine glands to
increase sweating, salivation, bronchial secretions, and secretion of gastric acid
How does bethanechol act on smooth muscle - CORRECT ANSWER- In smooth
muscles of the lungs and GI tract, muscarinic agonists promote contraction.
=constriction of the bronchi
= increased tone and motility of GI smooth muscle.
How does bethanechol act on the bladder - CORRECT ANSWER- Muscarinic activation
causes contraction of the detrusor muscle and relaxation of the trigone and
sphincter.
= bladder emptying.
What are muscarinic agonists? - CORRECT ANSWER- selectively mimic the effects of
acetylcholine at muscarinic receptors
What are cholinesterase inhibitors - CORRECT ANSWER- prevent the breakdown of
acetylcholine by acetylcholinesterase, as a result, more acetylcholine remains
available to activate cholinergic receptors
Activation of muscarinic receptors can produce what? - CORRECT ANSWER- ocular
effects (miosis and ciliary muscle contraction), slowing of heart rate, bronchial
constriction, urination, glandular secretion, stimulation of the gastrointestinal (GI)
tract, and vasodilation.
, How does bethanecol act on vasculature - CORRECT ANSWER- vascular smooth
muscle, these drugs cause relaxation; the resultant vasodilation can produce
hypotension
How does Bethanicol act on the eyes - CORRECT ANSWER- vascular smooth muscle,
these drugs cause relaxation; the resultant vasodilation can produce hypotension
effects of bethanechol are seen how quickly - CORRECT ANSWER- Effects begin in 30
to 60 minutes and persist for about 1 hour.
carries a positive change and crosses the membranes poorly.
What is bethanicol used to treat - CORRECT ANSWER- Although bethanechol can
produce a broad spectrum of pharmacologic effects, the drug is approved only for
urinary retention
How does bethanicol relieve unrinary retention - CORRECT ANSWER- activating
muscarinic receptors of the urinary tract
Muscarinic activation relaxes the trigone and sphincter muscles and increases
voiding pressure by contracting the detrusor muscle, which composes the bladder
wall.