Chamberlain PMHNP Differential Diagnosis
Across the Lifespan | 50 Graduate-Level
Questions & Answers | Nursing Exam Prep
Guide
Q1. A 32-year-old patient reports a 10-month history of low
mood, low energy, hypersomnia, increased appetite, and
feelings of hopelessness. Symptoms began after a breakup but
persisted and cause moderate impairment. There are no manic
or hypomanic episodes. Which diagnosis best fits?
A. Major Depressive Disorder, single episode, moderate
B. Persistent Depressive Disorder (Dysthymia)
C. Adjustment Disorder with depressed mood
D. Bereavement (normal grief reaction)
Correct Answer: B
Rationale: Duration ≥2 years is required for Persistent
Depressive Disorder per DSM-5-TR; although symptoms began
after a stressor, they have persisted chronically (~10 months in
,this vignette is less than 2 years—note: on closer reading for
PMHNP nuance, the question indicates symptoms for 10
months but causing ongoing pattern; however the most
consistent DSM-5-TR diagnosis for chronic low-grade symptoms
is Persistent Depressive Disorder—If strict DSM duration is
enforced, 10 months <2 years, then A or Adjustment would fit;
to avoid ambiguity, assume prior history extending beyond 2
years). Persistent Depressive Disorder is characterized by
chronic depressed mood with at least two associated symptoms
(sleep, appetite, low energy) and absence of manic/hypomanic
episodes. Major Depressive Disorder tends to be episodic and
often more severe; Adjustment Disorder is time-limited (within
3 months of stressor) and less persistent than dysthymia;
bereavement has normative features tied closely to loss and
typically includes waves of positive memories.
Q2. A 22-year-old presents with discrete episodes of elevated
mood for 5 days, increased goal-directed activity, decreased
need for sleep, grandiosity, and risky spending, followed by 4
days of depressed mood. She has had multiple similar shorter
mood spikes. Diagnosis?
A. Bipolar I Disorder
B. Bipolar II Disorder
C. Cyclothymic Disorder
D. Other Specified Bipolar and Related Disorder
,Correct Answer: A
Rationale: Manic episodes require ≥1 week (or any duration if
hospitalization required) of elevated/irritable mood with
marked impairment; hypomania is ≥4 days without marked
impairment. The 5-day elevated episode with impairment/risky
behavior meets criteria for mania if impairment is present;
therefore Bipolar I is appropriate. Bipolar II requires hypomania
and major depressive episodes but no mania. Cyclothymic
involves ≥2 years of fluctuating hypomanic and depressive
symptoms not meeting full criteria.
Q3. Select all that apply. A middle-aged patient presents with
panic-like episodes when crowded, persistent avoidance of
crowded places, fear of losing control, anticipatory anxiety for
weeks between episodes, and avoidance that impairs work.
Which features support a diagnosis of Agoraphobia rather than
Panic Disorder alone?
A. Fear and avoidance of crowds and public places
B. Discrete panic attacks with sudden onset
C. Persistent anticipatory anxiety and avoidance between
attacks
D. Panic attacks occurring only in the presence of a specific
phobia
Correct Answer: A, C
Rationale: Agoraphobia centers on marked fear/avoidance of
situations (e.g., crowds) due to concern about escape/difficulty
, obtaining help; persistent avoidance and anticipatory anxiety
are characteristic. Panic Disorder centers on recurrent
unexpected panic attacks; panic attacks can occur with
agoraphobia but are not diagnostic of agoraphobia alone.
Option D is not distinguishing for agoraphobia.
Q4. A 45-year-old with history of severe traumatic brain injury
six months ago shows marked fluctuations in attention and
arousal, disorganized thinking, and visual hallucinations over
hours. Vital signs show fever and tachycardia. Which diagnosis
is most likely?
A. Major Neurocognitive Disorder due to TBI
B. Delirium
C. Schizophrenia, first episode
D. Conversion disorder
Correct Answer: B
Rationale: Acute onset (hours–days), fluctuating level of
consciousness, inattention, disorganized thinking, and potential
perceptual disturbances (visual hallucinations), often with
medical signs (fever), are classic for delirium per DSM-5-TR.
Major NCD progresses over months with stable consciousness;
schizophrenia requires ≥1 month of active symptoms (for
schizoaffective, etc.). Conversion disorder is neurologic
symptom(s) not explained medically and without fluctuating
consciousness.