CSO Exam – 2026/2027 Updated Questions with Correct Answers

CSO Exam Questions With
Correct Answers


Alkylating agents mechanism of action - Answer Interfere with DNA bases, causing
breaks in DNA strands, thus preventing DNA replication and transcription of RNA

Bendamustine (Treanda) classification, route and indication - Answer Alkylating agent
IV
B-cell NHL, CLL

Bulsulfan (Myleran or Busulfex) classification, route and indication - Answer Alkylating
agent
Oral or IV
CML, hematopoietic cell transplantation preparation, polycythemia vera

Carboplatin (paraplatin) classification, route and indication - Answer Alkylating agent
IV
Cancers of the breast, bladder, cervix, endometrium, esophagus, germ cell, H&N, lung,
ovaries; sarcomas

Carmustine (BCNU) classification, route and indication - Answer Alkylating agent
IV
Brain cancer, Hodgkin disease, NHL, multiple myeloma, cutaneous T-cell lymphoma

Chlorambucil (Leukeran) classification, route and indication - Answer Alkylating agent
Oral
CLL, HD, NHL, cancers of breast, ovaries and testes

Cisplatin (Platinol, CDDP) classification, route and indication - Answer Alkylating agent
IV
Cancers of bladder, cervix, esophagus, head and neck, lung, prostate, ovaries, stomach
and testes; NHL

Cyclophosphamide (Cytoxan, CTX) classification, route and indication - Answer
Alkylating agent
IV, oral or intrapleural (IP)
Cancers of the breast, endometrium, lung, ovaries and testes; CLL, NHL, HD, MM,
neuroblastoma, Wilms' tumors, sarcomas

, Dacarbazine (DTIC) classification, route and indication - Answer Alkylating agent
IV
HD, malignant melanoma, neuroblastoma, sarcomas, medullary thyroid cancer

Ifosfamide (Ifex) classification, route and indication - Answer Alkylating agent
IV
Cancers of the bladder, cervix, germ cell, head and neck, and lung; HD; NHL; sarcomas

Mechlorethamine (aka nitrogen mustard) classification, route and indication - Answer
Alkylating agent
IV
CLL, CML, HD, NHL, mycosis fungoides, breast and lung cancers

Melphalan (Alkeran) classification, route and indication - Answer Alkylating agent
IV
Breast and ovarian cancers, MM, HCT, polycythemia vera, neuroblastoma

Oxaliplatin (Eloxatin) classification, route and indication - Answer Alkylating agent
IV
Colorectal cancer, pancreatic cancer

Temozolomide (Temodar) classification, route and indication - Answer Alkylating agent
Oral
Astrocytoma, glioblastoma

Thiotepa (Thioplex) classification, route and indication - Answer Alkylating agent
IV, IM, intrathecal (IT), subcutaneous (SC)
Bladder, breast and ovarian cancers; HD; NHL

Antimetabolites mechanism of action - Answer Interfere with DNA synthesis by acting
as false metabolites; incorporated into the DNA strand or block essential enzymes

Azacitidine (Vidaza) classification, route and indication - Answer Antimetabolite
Subcutaneous (SC) or IV
CML, MDS

Capecitabine (Xeloda) classification, route and indication - Answer Antimetabolite
Oral
Cancers of the colon, esophagus, pancreas, rectum, and (metastatic) breast

Cytarabine (ARA-C) classification, route and indication - Answer Antimetabolite
IV, SC, IT, IM
ALL, APL, AML, CML, NHL

Fludarabine (Fludara) classification, route and indication - Answer Antimetabolite
IV