Mastering Pain Relief: Ultimate Opioid Safety &
Medication Exam
150Q&A 2025-2026
1. Which opioid is considered the prototype for comparison with
other opioids?
A. Hydromorphone
B. Fentanyl
C. Morphine
D. Oxycodone
Morphine is the standard prototype opioid used to compare potency,
duration, and side-effect profiles.
2. Which medication is used to reverse opioid overdose?
A. Nalbuphine
B. Buprenorphine
C. Naloxone
D. Methadone
Naloxone is a pure opioid antagonist that rapidly reverses respiratory
depression.
3. Which pain medication is classified as a non-opioid analgesic?
A. Acetaminophen
B. Hydrocodone
C. Fentanyl
D. Methadone
Acetaminophen works centrally but is not an opioid; it treats mild to
moderate pain.
4. Which opioid has the highest potency?
,A. Morphine
B. Oxycodone
C. Codeine
D. Fentanyl
Fentanyl is extremely potent (50–100× stronger than morphine).
5. Which effect is most dangerous in opioid therapy?
A. Constipation
B. Sedation
C. Respiratory depression
D. Euphoria
Respiratory depression is the primary cause of opioid-related
mortality.
6. A patient taking morphine develops pinpoint pupils. This finding
represents:
A. Withdrawal
B. Allergic reaction
C. Infection
D. Opioid toxicity
Miosis is a classic sign of opioid overdose.
7. Which opioid should NOT be crushed due to risk of overdose?
A. Immediate-release oxycodone
B. Extended-release morphine
C. Tramadol
D. Hydrocodone
Crushing ER/CR opioids releases the full dose at once, causing fatal
overdose.
8. Which medication is used for neuropathic pain?
,A. Gabapentin
B. Morphine
C. Codeine
D. Hydromorphone
Gabapentin modulates calcium channels and is effective for
neuropathic pain.
9. A patient on opioids is most likely to develop which chronic side
effect?
A. Diarrhea
B. Pruritus
C. Sedation
D. Constipation
Opioids slow GI motility, causing persistent constipation.
10. Which opioid is safest in renal failure?
A. Morphine
B. Codeine
C. Fentanyl
D. Meperidine
Fentanyl has no active metabolites and is preferred in kidney disease.
11. Which medication is a mixed agonist-antagonist opioid?
A. Methadone
B. Buprenorphine
C. Hydromorphone
D. Fentanyl
Buprenorphine is a partial agonist with antagonist properties.
, 12. Which opioid is NOT recommended due to neurotoxic metabolite
accumulation?
A. Fentanyl
B. Meperidine
C. Hydrocodone
D. Oxycodone
Meperidine can accumulate normeperidine, causing seizures.
13. Which non-opioid medication reduces inflammation?
A. Acetaminophen
B. Tramadol
C. Ibuprofen
D. Methadone
NSAIDs inhibit prostaglandin synthesis and reduce inflammation.
14. What is the first-line treatment for opioid-induced constipation?
A. Decrease opioid dose
B. Stool softener + stimulant laxative
C. Antiemetic
D. Increase fluid intake only
Combination therapy prevents constipation more effectively than
softeners alone.
15. Which opioid is administered via transdermal patch?
A. Oxycodone
B. Morphine
C. Fentanyl
D. Hydromorphone
Fentanyl patches release medication slowly for chronic pain.
Medication Exam
150Q&A 2025-2026
1. Which opioid is considered the prototype for comparison with
other opioids?
A. Hydromorphone
B. Fentanyl
C. Morphine
D. Oxycodone
Morphine is the standard prototype opioid used to compare potency,
duration, and side-effect profiles.
2. Which medication is used to reverse opioid overdose?
A. Nalbuphine
B. Buprenorphine
C. Naloxone
D. Methadone
Naloxone is a pure opioid antagonist that rapidly reverses respiratory
depression.
3. Which pain medication is classified as a non-opioid analgesic?
A. Acetaminophen
B. Hydrocodone
C. Fentanyl
D. Methadone
Acetaminophen works centrally but is not an opioid; it treats mild to
moderate pain.
4. Which opioid has the highest potency?
,A. Morphine
B. Oxycodone
C. Codeine
D. Fentanyl
Fentanyl is extremely potent (50–100× stronger than morphine).
5. Which effect is most dangerous in opioid therapy?
A. Constipation
B. Sedation
C. Respiratory depression
D. Euphoria
Respiratory depression is the primary cause of opioid-related
mortality.
6. A patient taking morphine develops pinpoint pupils. This finding
represents:
A. Withdrawal
B. Allergic reaction
C. Infection
D. Opioid toxicity
Miosis is a classic sign of opioid overdose.
7. Which opioid should NOT be crushed due to risk of overdose?
A. Immediate-release oxycodone
B. Extended-release morphine
C. Tramadol
D. Hydrocodone
Crushing ER/CR opioids releases the full dose at once, causing fatal
overdose.
8. Which medication is used for neuropathic pain?
,A. Gabapentin
B. Morphine
C. Codeine
D. Hydromorphone
Gabapentin modulates calcium channels and is effective for
neuropathic pain.
9. A patient on opioids is most likely to develop which chronic side
effect?
A. Diarrhea
B. Pruritus
C. Sedation
D. Constipation
Opioids slow GI motility, causing persistent constipation.
10. Which opioid is safest in renal failure?
A. Morphine
B. Codeine
C. Fentanyl
D. Meperidine
Fentanyl has no active metabolites and is preferred in kidney disease.
11. Which medication is a mixed agonist-antagonist opioid?
A. Methadone
B. Buprenorphine
C. Hydromorphone
D. Fentanyl
Buprenorphine is a partial agonist with antagonist properties.
, 12. Which opioid is NOT recommended due to neurotoxic metabolite
accumulation?
A. Fentanyl
B. Meperidine
C. Hydrocodone
D. Oxycodone
Meperidine can accumulate normeperidine, causing seizures.
13. Which non-opioid medication reduces inflammation?
A. Acetaminophen
B. Tramadol
C. Ibuprofen
D. Methadone
NSAIDs inhibit prostaglandin synthesis and reduce inflammation.
14. What is the first-line treatment for opioid-induced constipation?
A. Decrease opioid dose
B. Stool softener + stimulant laxative
C. Antiemetic
D. Increase fluid intake only
Combination therapy prevents constipation more effectively than
softeners alone.
15. Which opioid is administered via transdermal patch?
A. Oxycodone
B. Morphine
C. Fentanyl
D. Hydromorphone
Fentanyl patches release medication slowly for chronic pain.
