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Exam (elaborations)

BSN 315 HESI Exam 2025: Study Guide, Practice Questions & Test Blueprint

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Get ready for your BSN 315 HESI exam with this 2025 guide. Includes a comprehensive subject review, practice questions, test-taking strategies, and a blueprint of key nursing concepts for advanced medical-surgical or complex care coursework.

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December 5, 2025
Number of pages
706
Written in
2025/2026
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BSN 315 HESI 2025, RN pharmacology exam,
HESI specialty pharmacology, nursing
pharmacology questions, verified HESI answers,
HESI RN exam prep, 2025 nursing test




A healthcare provider prescribes cephalexin
monohydrate (Keflex) for a client with a postoperative
infection. It is most important for the nurse to assess for
what additional drug allergy before administering this
prescription?
A) Penicillins.
B) Aminoglycosides.
C) Erythromycins.
D) Sulfonamides. - .....ANSWER ...✔✔ A) Penicillins.


Cross-allergies exist between penicillins (A) and
cephalosporins, such as cephalexin monohydrate
(Keflex), so checking for penicillin allergy is a wise
precaution before administering this drug.


Which nursing intervention is most important when caring
for a client receiving the antimetabolite cytosine
arabinoside (Arc-C) for chemotherapy?

,2|Page



A) Hydrate the client with IV fluids before and after
infusion.
B) Assess the client for numbness and tingling of
extremities.
C) Inspect the client's oral mucosa for ulcerations.
D) Monitor the client's urine pH for increased acidity. -
.....ANSWER ...✔✔ C) Inspect the client's oral mucosa
for ulcerations.


Cytosine arabinoside (Arc-C) affects the rapidly
growing cells of the body, therefore stomatitis and
mucosal ulcerations are key signs of antimetabolite
toxicity (C). (A, B, and D) are not typical interventions
associated with the administration of antimetabolites.


When assessing an adolescent who recently overdosed
on acetaminophen (Tylenol), it is most important for the
nurse to assess for pain in which area of the body?
A) Flank.
B) Abdomen.
C) Chest.
D) Head. - .....ANSWER ...✔✔ B) Abdomen.

,3|Page



Acetaminophen toxicity can result in liver damage;
therefore, it is especially important for the nurse to
assess for pain in the right upper quadrant of the
abdomen (B), which might indicate liver damage. (A, C,
and D) are not areas where pain would be anticipated.


An adult client is given a prescription for a scopolamine
patch (Transderm Scop) to prevent motion sickness while
on a cruise. Which information should the nurse provide
to the client?
A) Apply the patch at least 4 hours prior to departure.
B) Change the patch every other day while on the cruise.
C) Place the patch on a hairless area at the base of the
skull.
D) Drink no more than 2 alcoholic drinks during the
cruise. - .....ANSWER ...✔✔ A) Apply the patch at
least 4 hours prior to departure.


Scopolamine, an anticholinergic agent, is used to prevent
motion sickness and has a peak onset in 6 hours, so the
client should be instructed to apply the patch at least 4
hours before departure (A) on the cruise ship. The
duration of the transdermal patch is 72 hours, so (B) is
not needed. Scolopamine blocks muscarinic receptors in
the inner ear and to the vomiting center, so the best
application site of the patch is behind the ear, not at the

, 4|Page



base of the skull (C). Anticholinergic medications are
CNS depressants, so the client should be instructed to
avoid alcohol (D) while using the patch.


The nurse is reviewing the use of the patient-controlled
analgesia (PCA) pump with a client in the immediate
postoperative period. The client will receive morphine 1
mg IV per hour basal rate with 1 mg IV every 15
minutes per PCA to total 5 mg IV maximally per hour.
What assessment has the highest priority before
initiating the PCA pump?
A) The expiration date on the morphine syringe in the
pump.
B) The rate and depth of the client's respirations.
C) The type of anesthesia used during the surgical
procedure.
D) The client's subjective and objective signs of pain. -
.....ANSWER ...✔✔ B) The rate and depth of the
client's respirations.


A life-threatening side effect of intravenous
administration of morphine sulfate, an opiate narcotic, is
respiratory depression (B). The PCA pump should be
stopped and the healthcare provider notified if the
client's respiratory rate falls below 12 breaths per
minute, and the nurse should anticipate adjustments in
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