Biochem test 2 EXAM QUESTIONS
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SOLUTIONS||ALREADY
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Which of the following amino acids cannot be used to provide an intermediate of
the citric acid cycle?
a. Histidine
b. Proline
c. Lysine
d. Tyrosine
e. Phenylalanine - ANSWER ✓ c. Lysine
What is the role of PrPP in nucleotide metabolism?
a. Donates carbons to the rings on growing nucleotides
b. Forms pyrimidines together, but not purines
c. Contains the ribose and phosphates that the pyrimidines and purines attach to
d. Is used as energy in common sugar metabolism
e. None of the above - ANSWER ✓ c. Contains the ribose and phosphates that the
pyrimidines and purines attach to
Which of the following compounds is NOT a precursor for nucleotide
biosynthesis?
a. Carbamoyl phosphate
b. Fumarate
c. Glutamine
d. Glycine
e. Asparatate - ANSWER ✓ b. Fumarate
What are exosomes?
a. Exosomes are sub-cellular vesicales released into bodily fluids
b. Exosomes are protein chains
c. Exosomes are comprised of fats, and form structures similar to micelles
d. Exosomes are bundles of DNA
, e. None of the above - ANSWER ✓ a. Exosomes are sub-cellular vesicales
released into bodily fluids
How were exosomal and non-exosomal fractions isolated?
a. Various centrifugation steps
b. Immunoblotting on whole samples
c. Selective column
d. PCR for exosomal genes
e. All of the above - ANSWER ✓ a. Various centrifugation steps
When examining the presence of phosphorylated tau (AT270+) in exosomes, the
authors found bands of different sizes of various sizes but expected a single weight
for this single protein. How did the authors explain this discrepancy?
a. The multiple bands represented mono-, di-, and tri- oligomers
b. Binding of tau to NFTs, neurofibrillary tangles
c. Binding of tau to other proteins
d. All of the above
e. None of the above - ANSWER ✓ d. All of the above
The authors find elevated AT270+ phosphorylated tau in mild/moderate
Alzheimer's Disease patients, but levels in severe AD patients are not.
a. Phosphorylated tau was found to correlate with neuronal death, and neuronal
death was greater in the mild/ moderate patients.
b. The exosomal mechanism of excretion allows for tau to interact with other
proteins aggregated in neuronal disease states and these interactions may cause the
observed neurotoxicity
c. At the most severe cases, tau is elevated. This finding in the severe patients was
an outlier.
d. Tau serves a protective role in the mild patients before the disease progresses to
a severe state
e. None of the above - ANSWER ✓ b. The exosomal mechanism of excretion
allows for tau to interact with other proteins aggregated in neuronal disease states
and these interactions may cause the observed neurotoxicity
The authors explain the importance of tau by stating "tau alterations such as
phosphorylation, cleavage, and oligomerization suggest that secretion may play a
significant role in tau-associated neurodegeneration." What effects might these
events have on the protein?
WITH CORRECT
SOLUTIONS||ALREADY
GRADED||100% GUARANTEED
PASS||<<NEWEST VERSION>>
Which of the following amino acids cannot be used to provide an intermediate of
the citric acid cycle?
a. Histidine
b. Proline
c. Lysine
d. Tyrosine
e. Phenylalanine - ANSWER ✓ c. Lysine
What is the role of PrPP in nucleotide metabolism?
a. Donates carbons to the rings on growing nucleotides
b. Forms pyrimidines together, but not purines
c. Contains the ribose and phosphates that the pyrimidines and purines attach to
d. Is used as energy in common sugar metabolism
e. None of the above - ANSWER ✓ c. Contains the ribose and phosphates that the
pyrimidines and purines attach to
Which of the following compounds is NOT a precursor for nucleotide
biosynthesis?
a. Carbamoyl phosphate
b. Fumarate
c. Glutamine
d. Glycine
e. Asparatate - ANSWER ✓ b. Fumarate
What are exosomes?
a. Exosomes are sub-cellular vesicales released into bodily fluids
b. Exosomes are protein chains
c. Exosomes are comprised of fats, and form structures similar to micelles
d. Exosomes are bundles of DNA
, e. None of the above - ANSWER ✓ a. Exosomes are sub-cellular vesicales
released into bodily fluids
How were exosomal and non-exosomal fractions isolated?
a. Various centrifugation steps
b. Immunoblotting on whole samples
c. Selective column
d. PCR for exosomal genes
e. All of the above - ANSWER ✓ a. Various centrifugation steps
When examining the presence of phosphorylated tau (AT270+) in exosomes, the
authors found bands of different sizes of various sizes but expected a single weight
for this single protein. How did the authors explain this discrepancy?
a. The multiple bands represented mono-, di-, and tri- oligomers
b. Binding of tau to NFTs, neurofibrillary tangles
c. Binding of tau to other proteins
d. All of the above
e. None of the above - ANSWER ✓ d. All of the above
The authors find elevated AT270+ phosphorylated tau in mild/moderate
Alzheimer's Disease patients, but levels in severe AD patients are not.
a. Phosphorylated tau was found to correlate with neuronal death, and neuronal
death was greater in the mild/ moderate patients.
b. The exosomal mechanism of excretion allows for tau to interact with other
proteins aggregated in neuronal disease states and these interactions may cause the
observed neurotoxicity
c. At the most severe cases, tau is elevated. This finding in the severe patients was
an outlier.
d. Tau serves a protective role in the mild patients before the disease progresses to
a severe state
e. None of the above - ANSWER ✓ b. The exosomal mechanism of excretion
allows for tau to interact with other proteins aggregated in neuronal disease states
and these interactions may cause the observed neurotoxicity
The authors explain the importance of tau by stating "tau alterations such as
phosphorylation, cleavage, and oligomerization suggest that secretion may play a
significant role in tau-associated neurodegeneration." What effects might these
events have on the protein?
