Unit 5: Anticoagulants, Antiplatelets, +
Thrombolytics CNUR 202 Questions
and Revised Answers 2025-2026
Edition.
What is the mechanism of action for anticoagulants? - Answer Inhibit the action or
formation of clotting factors
NOTE: no effect on a blood clot that is already formed
What are the indications for anticoagulants? (6) - Answer - MI
- Unstable angina
- Atrial fibrillation
- Artificial heart valves
- Conditions with slowed blood flow
- Prolonged periods of immobility
What is the mechanism of action for heparin? - Answer Binds to antithrombin III and
inactivates thrombin, factor Xa, factor IXa
What is the antidote for heparin? - Answer Protamine sulfate
What is the mechanism of action for LMWHs? - Answer Inhibits factor Xa and thrombin
What is tinzaparin dosage based on? - Answer weight (kg)
What are the most common side effects of heparins and LMWHs? (2) - Answer - Anemia
- Bruising at the injection site
What are the most common adverse effects of heparins and LMWHs? (2) - Answer - Bleeding
- Thrombocytopenia
, What are the common adverse effects of warfarin (Coumadin)? (2) - Answer - Bleeding
- Calciphylaxis
What is the antidote for warfarin? - Answer Vitamin K
What is the major drug interaction with anticoagulants? - Answer Use with aspirin/NSAIDs
What is the general mechanism of action for all antiplatelet drugs? - Answer Prevent platelet
adhesion
What is a common antiplatelet medication? - Answer - Aspirin
What is the main indication for aspirin? - Answer Stroke/MI prophylaxis
What are the indications for platelet P2Y12 receptor antagonists? - Answer Secondary
prevention of atherothrombotic events (MI, stroke, and vascular death) in patients with
atherosclerosis
What is the indication for dipyridamole/ASA? - Answer Prevention of stroke in patients who
have had a previous stroke or TIA
What is the indication of pentoxifylline? - Answer Symptomatic treatment of patients with
chronic occlusive peripheral vascular disorders of the extremeties
What is the general mechanism of action for thrombolytic drugs/ - Answer Activate the
fibrinolytic system to break down a clot in the blood vessel quickly.
Activate plasminogen and convert it to plasmin, which can digest fibrin.
Re-establish blood flow to the area that was being blocked by the clot.
What are the indications for thrombolytic drugs? - Answer - Acute MI
- Arterial thrombosis
Thrombolytics CNUR 202 Questions
and Revised Answers 2025-2026
Edition.
What is the mechanism of action for anticoagulants? - Answer Inhibit the action or
formation of clotting factors
NOTE: no effect on a blood clot that is already formed
What are the indications for anticoagulants? (6) - Answer - MI
- Unstable angina
- Atrial fibrillation
- Artificial heart valves
- Conditions with slowed blood flow
- Prolonged periods of immobility
What is the mechanism of action for heparin? - Answer Binds to antithrombin III and
inactivates thrombin, factor Xa, factor IXa
What is the antidote for heparin? - Answer Protamine sulfate
What is the mechanism of action for LMWHs? - Answer Inhibits factor Xa and thrombin
What is tinzaparin dosage based on? - Answer weight (kg)
What are the most common side effects of heparins and LMWHs? (2) - Answer - Anemia
- Bruising at the injection site
What are the most common adverse effects of heparins and LMWHs? (2) - Answer - Bleeding
- Thrombocytopenia
, What are the common adverse effects of warfarin (Coumadin)? (2) - Answer - Bleeding
- Calciphylaxis
What is the antidote for warfarin? - Answer Vitamin K
What is the major drug interaction with anticoagulants? - Answer Use with aspirin/NSAIDs
What is the general mechanism of action for all antiplatelet drugs? - Answer Prevent platelet
adhesion
What is a common antiplatelet medication? - Answer - Aspirin
What is the main indication for aspirin? - Answer Stroke/MI prophylaxis
What are the indications for platelet P2Y12 receptor antagonists? - Answer Secondary
prevention of atherothrombotic events (MI, stroke, and vascular death) in patients with
atherosclerosis
What is the indication for dipyridamole/ASA? - Answer Prevention of stroke in patients who
have had a previous stroke or TIA
What is the indication of pentoxifylline? - Answer Symptomatic treatment of patients with
chronic occlusive peripheral vascular disorders of the extremeties
What is the general mechanism of action for thrombolytic drugs/ - Answer Activate the
fibrinolytic system to break down a clot in the blood vessel quickly.
Activate plasminogen and convert it to plasmin, which can digest fibrin.
Re-establish blood flow to the area that was being blocked by the clot.
What are the indications for thrombolytic drugs? - Answer - Acute MI
- Arterial thrombosis
