Dermatology
Study online at https://quizlet.com/_hvz7em
1. Acne vulgaris disease of pilosebaceous unit d/t increased sebum production, follicular hyperk-
eratinization, increased Cutibacterium acnes within follicle, and inflammation via
innate immune system d/t free fatty acids produced by bacteria
2. cutibacterium ac- gram positive anaerobic rod present on skinn that produces lipases splitting
nes sebum triglycerides into glycerol and free fatty acids leading to inflammation and
formation of Acne vulgaris
3. sebum oily exocrine secretion from sebaceous glands onto hair follicle; stimulation by
androgens during puberty
4. follicular hyperk- excessive skin cell productoin leading to obstruction of pilosebaceous unit d/t
eratinization anomalies of proliferation, adhesion, and differentiation in follicular lumen
5. comedones acne precursor lesion from blockage of pilosebaceous unit
6. open comedone flesh colored papules with dilated follicular ostial filled with black material (black-
heads)
7. closed come- flesh colored papules without dilated follicular ostia (whiteheads)
dones
8. inflammatory inflammatory (erythematous) papules and pustules, mainly superficial lesions that
acne are folliculocentric
9. nodulocystic severe, deep inflammatory nodules and sinus tracts leading to acne scarring
acne
10. acne scarring atrophic scars on the face with untreated deep inflammatory acne; inflammatory
cell infiltrates may persist
11. retinoids first line agent for correcting defects in keratinization by normalizing keratinocyte
(tretinoin) differentiation in follicular infundibulum and decreasing KC adhesion allowing for
normal desquamation
, Dermatology
Study online at https://quizlet.com/_hvz7em
12. Benzoyl peroxide first line agent for reducing C. acnes population; destroy bacteria via oxidation
13. Intralesional cor- local agent injected into lesion to produce anti-inflammatory effect to treat acne
ticosteroids
14. Doxycyline first line systemic treatment for producing anti-inflammatory effect and killing C.
(minocycline) acnes to treat acne
15. Oral contracep- first line treatment for decreasing sebaceous gland activity to treat acne; reserved
tive pills for females
16. spironolactone second line treatment for decreasing sebaceous gland activity to treat acne;
contraindicated during pregnancy, use with cautino with other potassium sparing
diuretics
17. Isotretinoin (ac- most effective agent for severe inflammatory acne causing permanent remission
cutane) in 40%
18. isotretinoin (ac- treatment for acne vulgaris via decreasing sebum production, reduction in C.
cutane) acnes, correcting defects in keratinization by normalizing KC differentiation
19. Isotretinoin (ac- Severe acne treatment with severe side effects; potent teratogen, mucocutaneous
cutane) dryness, hyperlipidemia, boney spurs and ossification of ligaments, closure of
epiphyses, osteoporosis of long bones, depression and IBD
20. Acne Rosacea central face chronic inflammatory disorder d/t genetics, vascular hyperreactivity,
chronic solar damage, heat sensitivity, hyperirritable skin, and demodex
21. Erythematote- Rosacea subtype causing central face recurrent blushing with burning and sting-
langiectatic ing
(vascular)
rosacea
, Dermatology
Study online at https://quizlet.com/_hvz7em
22. Papulopustular Rosacea subtype; similar to acne vulgaris, lesions with deeper red and no come-
(inflammatory) dones; transient papules/pustules
rosacea
23. phymatous rosacea subtype; overgrowth of sebaceous glands, thickening of skin, nose com-
rosacea monly affected; treat sith nasal planing and CO2 laser
24. Ocular rosacea rosacea subtype; ocular involvement with dryness, foreign body sensation, burn-
ing/stinging
25. metronidazole topical antibiotic used to reduce inflammation in papule/pustular rosacea
(topical
ivermectin)
26. Tetracyclines second line antibiotic used to reduce inflammation in papule/pustular rosacea
27. topical vasocon- second line treatment after avoidance of triggers for erythema/telangiectasia
strictors rosacea subtype
28. Perioral/periorifi- rosaceap-like papular or eczematous rash centered around mouth and nasolabial
cial dermatitis fold; steroids can induce
29. Anagen growth phase of hair follicle, 905 of hair in this phase; length of phase determines
hair length
30. telogen resting phase of hair follicle; new anagen hair pushes out old hair with resulting
hair loss
31. Androgenetic hair loss d/t aging, men>female with different pattenr; increased androgen pro-
alopecia duction cause; shortened anagen phase-->follicular miniaturization
32. finasteride 5-alpha reductase inhibitor used to treat androgenetic alopecia
33. minoxidil
Study online at https://quizlet.com/_hvz7em
1. Acne vulgaris disease of pilosebaceous unit d/t increased sebum production, follicular hyperk-
eratinization, increased Cutibacterium acnes within follicle, and inflammation via
innate immune system d/t free fatty acids produced by bacteria
2. cutibacterium ac- gram positive anaerobic rod present on skinn that produces lipases splitting
nes sebum triglycerides into glycerol and free fatty acids leading to inflammation and
formation of Acne vulgaris
3. sebum oily exocrine secretion from sebaceous glands onto hair follicle; stimulation by
androgens during puberty
4. follicular hyperk- excessive skin cell productoin leading to obstruction of pilosebaceous unit d/t
eratinization anomalies of proliferation, adhesion, and differentiation in follicular lumen
5. comedones acne precursor lesion from blockage of pilosebaceous unit
6. open comedone flesh colored papules with dilated follicular ostial filled with black material (black-
heads)
7. closed come- flesh colored papules without dilated follicular ostia (whiteheads)
dones
8. inflammatory inflammatory (erythematous) papules and pustules, mainly superficial lesions that
acne are folliculocentric
9. nodulocystic severe, deep inflammatory nodules and sinus tracts leading to acne scarring
acne
10. acne scarring atrophic scars on the face with untreated deep inflammatory acne; inflammatory
cell infiltrates may persist
11. retinoids first line agent for correcting defects in keratinization by normalizing keratinocyte
(tretinoin) differentiation in follicular infundibulum and decreasing KC adhesion allowing for
normal desquamation
, Dermatology
Study online at https://quizlet.com/_hvz7em
12. Benzoyl peroxide first line agent for reducing C. acnes population; destroy bacteria via oxidation
13. Intralesional cor- local agent injected into lesion to produce anti-inflammatory effect to treat acne
ticosteroids
14. Doxycyline first line systemic treatment for producing anti-inflammatory effect and killing C.
(minocycline) acnes to treat acne
15. Oral contracep- first line treatment for decreasing sebaceous gland activity to treat acne; reserved
tive pills for females
16. spironolactone second line treatment for decreasing sebaceous gland activity to treat acne;
contraindicated during pregnancy, use with cautino with other potassium sparing
diuretics
17. Isotretinoin (ac- most effective agent for severe inflammatory acne causing permanent remission
cutane) in 40%
18. isotretinoin (ac- treatment for acne vulgaris via decreasing sebum production, reduction in C.
cutane) acnes, correcting defects in keratinization by normalizing KC differentiation
19. Isotretinoin (ac- Severe acne treatment with severe side effects; potent teratogen, mucocutaneous
cutane) dryness, hyperlipidemia, boney spurs and ossification of ligaments, closure of
epiphyses, osteoporosis of long bones, depression and IBD
20. Acne Rosacea central face chronic inflammatory disorder d/t genetics, vascular hyperreactivity,
chronic solar damage, heat sensitivity, hyperirritable skin, and demodex
21. Erythematote- Rosacea subtype causing central face recurrent blushing with burning and sting-
langiectatic ing
(vascular)
rosacea
, Dermatology
Study online at https://quizlet.com/_hvz7em
22. Papulopustular Rosacea subtype; similar to acne vulgaris, lesions with deeper red and no come-
(inflammatory) dones; transient papules/pustules
rosacea
23. phymatous rosacea subtype; overgrowth of sebaceous glands, thickening of skin, nose com-
rosacea monly affected; treat sith nasal planing and CO2 laser
24. Ocular rosacea rosacea subtype; ocular involvement with dryness, foreign body sensation, burn-
ing/stinging
25. metronidazole topical antibiotic used to reduce inflammation in papule/pustular rosacea
(topical
ivermectin)
26. Tetracyclines second line antibiotic used to reduce inflammation in papule/pustular rosacea
27. topical vasocon- second line treatment after avoidance of triggers for erythema/telangiectasia
strictors rosacea subtype
28. Perioral/periorifi- rosaceap-like papular or eczematous rash centered around mouth and nasolabial
cial dermatitis fold; steroids can induce
29. Anagen growth phase of hair follicle, 905 of hair in this phase; length of phase determines
hair length
30. telogen resting phase of hair follicle; new anagen hair pushes out old hair with resulting
hair loss
31. Androgenetic hair loss d/t aging, men>female with different pattenr; increased androgen pro-
alopecia duction cause; shortened anagen phase-->follicular miniaturization
32. finasteride 5-alpha reductase inhibitor used to treat androgenetic alopecia
33. minoxidil
