PHARMACOLOGY CLEAR AND SIMPLE 4TH EDITION
STUDY GUIDE 2026 – COMPLETE CONCEPT REVIEW &
PRACTICE MATERIALS (LATEST EDITION
PHARMACOLOGY CLEAR AND SIMPLE 4TH EDITION - CONCEPT REVIEW & PRACTICE
Chapter 1: Introduction to Pharmacology
1. The study of what the body does to a drug is called:
A. Pharmacotherapeutics
B. Pharmacodynamics
C. ✓ Pharmacokinetics
D. Toxicology
2. The generic name of a drug is also known as its:
A. Brand name
B. ✓ Nonproprietary name
C. Chemical name
D. Proprietary name
3. The phase of clinical testing that involves first administration to a small group of healthy
human volunteers is:
A. Phase I
B. Phase II
C. ✓ Phase I
D. Phase IV
4. Which branch of pharmacology deals with the use of drugs to treat disease?
A. Pharmacokinetics
B. ✓ Pharmacotherapeutics
C. Pharmacognosy
D. Toxicology
5. The "Orange Book" published by the FDA is a resource for:
A. Drug toxicities
B. ✓ Therapeutic equivalence of generic drugs
C. Herbal supplement regulations
D. New drug applications
Chapter 2: Drug Legislation and Regulation
,6. The law that required drugs to be proven safe before marketing was the:
A. Pure Food and Drug Act of 1906
B. ✓ Food, Drug, and Cosmetic Act of 1938
C. Kefauver-Harris Amendment of 1962
D. Controlled Substances Act of 1970
7. Which schedule of controlled substances has the highest potential for abuse and no
accepted medical use?
A. Schedule II
B. Schedule III
C. ✓ Schedule I
D. Schedule V
8. The Kefauver-Harris Amendment was passed in response to which event?
A. Elixir of Sulfanilamide tragedy
B. ✓ Thalidomide tragedy
C. Opioid epidemic
D. Tylenol tampering crisis
9. A medication guide (MedGuide) is required by the FDA for drugs that:
A. Are over-the-counter
B. ✓ Pose a serious public health concern
C. Are new to the market
D. Are available in generic form
10. The DEA primarily enforces laws related to:
A. Drug pricing
B. ✓ Controlled substances
C. Drug advertising
D. Patent protection
Chapter 3: Principles of Drug Administration
11. The "five rights" of medication administration do NOT include:
A. Right patient
B. Right drug
C. Right time
D. ✓ Right diagnosis
12. Enteric-coated tablets are designed to:
A. Dissolve quickly in the stomach
,B. Provide a sustained release of medication
C. ✓ Dissolve in the small intestine, not the stomach
D. Mask an unpleasant taste
13. The Z-track technique is used for which type of injection?
A. Subcutaneous
B. Intradermal
C. ✓ Intramuscular
D. Intravenous
14. Which route bypasses first-pass metabolism?
A. Oral
B. Rectal
C. ✓ Sublingual
D. All of the above bypass it
15. A drug order that is to be given "PRN" is administered:
A. Once daily
B. ✓ As needed
C. Immediately
D. At bedtime
Chapter 4: Pharmacokinetics
16. The process by which a drug moves from its site of administration into the bloodstream is:
A. Distribution
B. Metabolism
C. ✓ Absorption
D. Excretion
17. The primary site of drug metabolism in the body is the:
A. Kidneys
B. Lungs
C. ✓ Liver
D. Stomach
18. The time it takes for the plasma concentration of a drug to be reduced by 50% is its:
A. Therapeutic index
B. ✓ Half-life
C. Peak level
D. Steady state
, 19. First-pass effect primarily affects drugs given by which route?
A. Intravenous
B. ✓ Oral
C. Inhalation
D. Transdermal
20. The process where drugs are transported by blood plasma proteins is called:
A. Metabolism
B. ✓ Protein binding
C. Glomerular filtration
D. Active transport
Chapter 5: Pharmacodynamics
21. An agonist is a drug that:
A. Blocks a receptor
B. ✓ Binds to a receptor and produces a response
C. Has no intrinsic activity
D. Antagonizes an endogenous substance
22. The therapeutic index (TI) is a ratio of:
A. ED50 to TD50
B. ✓ LD50 to ED50
C. Potency to Efficacy
D. Peak level to trough level
23. A drug with high potency:
A. Always has high efficacy
B. ✓ Produces a response at a low dose
C. Has a wide therapeutic window
D. Is always safer
24. The term "efficacy" refers to a drug's:
A. Safety margin
B. ✓ Maximum therapeutic effect it can produce
C. Speed of onset
D. Affinity for a receptor
25. A drug that binds to a receptor but causes no response, blocking agonists, is a(n):
A. Partial agonist
B. Inverse agonist
STUDY GUIDE 2026 – COMPLETE CONCEPT REVIEW &
PRACTICE MATERIALS (LATEST EDITION
PHARMACOLOGY CLEAR AND SIMPLE 4TH EDITION - CONCEPT REVIEW & PRACTICE
Chapter 1: Introduction to Pharmacology
1. The study of what the body does to a drug is called:
A. Pharmacotherapeutics
B. Pharmacodynamics
C. ✓ Pharmacokinetics
D. Toxicology
2. The generic name of a drug is also known as its:
A. Brand name
B. ✓ Nonproprietary name
C. Chemical name
D. Proprietary name
3. The phase of clinical testing that involves first administration to a small group of healthy
human volunteers is:
A. Phase I
B. Phase II
C. ✓ Phase I
D. Phase IV
4. Which branch of pharmacology deals with the use of drugs to treat disease?
A. Pharmacokinetics
B. ✓ Pharmacotherapeutics
C. Pharmacognosy
D. Toxicology
5. The "Orange Book" published by the FDA is a resource for:
A. Drug toxicities
B. ✓ Therapeutic equivalence of generic drugs
C. Herbal supplement regulations
D. New drug applications
Chapter 2: Drug Legislation and Regulation
,6. The law that required drugs to be proven safe before marketing was the:
A. Pure Food and Drug Act of 1906
B. ✓ Food, Drug, and Cosmetic Act of 1938
C. Kefauver-Harris Amendment of 1962
D. Controlled Substances Act of 1970
7. Which schedule of controlled substances has the highest potential for abuse and no
accepted medical use?
A. Schedule II
B. Schedule III
C. ✓ Schedule I
D. Schedule V
8. The Kefauver-Harris Amendment was passed in response to which event?
A. Elixir of Sulfanilamide tragedy
B. ✓ Thalidomide tragedy
C. Opioid epidemic
D. Tylenol tampering crisis
9. A medication guide (MedGuide) is required by the FDA for drugs that:
A. Are over-the-counter
B. ✓ Pose a serious public health concern
C. Are new to the market
D. Are available in generic form
10. The DEA primarily enforces laws related to:
A. Drug pricing
B. ✓ Controlled substances
C. Drug advertising
D. Patent protection
Chapter 3: Principles of Drug Administration
11. The "five rights" of medication administration do NOT include:
A. Right patient
B. Right drug
C. Right time
D. ✓ Right diagnosis
12. Enteric-coated tablets are designed to:
A. Dissolve quickly in the stomach
,B. Provide a sustained release of medication
C. ✓ Dissolve in the small intestine, not the stomach
D. Mask an unpleasant taste
13. The Z-track technique is used for which type of injection?
A. Subcutaneous
B. Intradermal
C. ✓ Intramuscular
D. Intravenous
14. Which route bypasses first-pass metabolism?
A. Oral
B. Rectal
C. ✓ Sublingual
D. All of the above bypass it
15. A drug order that is to be given "PRN" is administered:
A. Once daily
B. ✓ As needed
C. Immediately
D. At bedtime
Chapter 4: Pharmacokinetics
16. The process by which a drug moves from its site of administration into the bloodstream is:
A. Distribution
B. Metabolism
C. ✓ Absorption
D. Excretion
17. The primary site of drug metabolism in the body is the:
A. Kidneys
B. Lungs
C. ✓ Liver
D. Stomach
18. The time it takes for the plasma concentration of a drug to be reduced by 50% is its:
A. Therapeutic index
B. ✓ Half-life
C. Peak level
D. Steady state
, 19. First-pass effect primarily affects drugs given by which route?
A. Intravenous
B. ✓ Oral
C. Inhalation
D. Transdermal
20. The process where drugs are transported by blood plasma proteins is called:
A. Metabolism
B. ✓ Protein binding
C. Glomerular filtration
D. Active transport
Chapter 5: Pharmacodynamics
21. An agonist is a drug that:
A. Blocks a receptor
B. ✓ Binds to a receptor and produces a response
C. Has no intrinsic activity
D. Antagonizes an endogenous substance
22. The therapeutic index (TI) is a ratio of:
A. ED50 to TD50
B. ✓ LD50 to ED50
C. Potency to Efficacy
D. Peak level to trough level
23. A drug with high potency:
A. Always has high efficacy
B. ✓ Produces a response at a low dose
C. Has a wide therapeutic window
D. Is always safer
24. The term "efficacy" refers to a drug's:
A. Safety margin
B. ✓ Maximum therapeutic effect it can produce
C. Speed of onset
D. Affinity for a receptor
25. A drug that binds to a receptor but causes no response, blocking agonists, is a(n):
A. Partial agonist
B. Inverse agonist
