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HESI & NGN Pharmacology Practice Exam – 100 Questions with Rationales 2025/2026

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Prepare effectively for the HESI RN and Next Generation NCLEX (NGN) exams with this comprehensive 100-question Pharmacology practice test. Each question includes detailed rationales, covering drug classes, mechanisms of action, therapeutic uses, adverse effects, and nursing considerations. Ideal for nursing students seeking mastery in pharmacology concepts and exam readiness. Updated for 2025/2026 standards.

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HESI + NGN Pharmacology
Course
HESI + NGN Pharmacology











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Institution
HESI + NGN Pharmacology
Course
HESI + NGN Pharmacology

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Uploaded on
November 29, 2025
Number of pages
53
Written in
2025/2026
Type
Exam (elaborations)
Contains
Questions & answers

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HESI + NGN Pharmacology Practice Exam (100
Questions)
🟦 PART I — NGN-STYLE CASE STUDIES (25 QUESTIONS)
=============================
📘 CASE STUDY 1 — HEART FAILURE (5 NGN QUESTIONS)


Patient:
72-year-old male with acute decompensated heart failure.
Meds: Furosemide IV, Lisinopril PO, Metoprolol succinate, Potassium chloride.


1. (Matrix — Expected vs Unexpected Findings)


Drag each assessment finding to the correct column.


Dizziness


Potassium 3.0 mEq/L


BP 162/92


Dry cough


HR 58 bpm


Expected: (Normal effects of meds)
Unexpected: (Adverse/complications)


Answer:
Expected: HR 58 bpm, Dry cough
Unexpected: K⁺ 3.0, BP 162/92, Dizziness

,HESI + NGN Pharmacology Practice Exam (100
Questions)

Rationale:


ACE inhibitors → dry cough (expected).


Beta-blockers → bradycardia (expected if mild).


Hypokalemia, hypertension, dizziness indicate problems.


2. (Multiple-response)


Which findings indicate furosemide is working?


A. Decreased crackles


B. Weight loss


C. K⁺ 2.9 mEq/L


D. BP 198/110


E. Increased urine output


Answer: A, B, E
Rationale: Diuretics improve breathing, promote diuresis, and reduce fluid
weight.


3. (Cloze — Fill-in trend)

,HESI + NGN Pharmacology Practice Exam (100
Questions)

Before next furosemide dose, the nurse should prioritize monitoring ______.


Answer: Potassium level
Rationale: Loop diuretics cause significant K⁺ loss → life-threatening
arrhythmias.


4. (Single-response)


Which statement indicates correct patient teaching?


A. “I will avoid foods high in potassium.”


B. “I may feel a little dizzy when standing.”


C. “I should stop metoprolol if my heart rate drops below 60.”


D. “ACE inhibitors may cause swelling of the ankles.”


Answer: B
Rationale: Orthostatic hypotension is expected with these meds.


5. (Priority)


Which symptom requires immediate action?


A. Fatigue

, HESI + NGN Pharmacology Practice Exam (100
Questions)
B. Nonproductive cough


C. Facial swelling


D. Mild dizziness


Answer: C
Rationale: Angioedema from ACE inhibitors is LIFE-THREATENING.


📘 CASE STUDY 2 — TYPE 1 DIABETES (5 QUESTIONS)


Patient:
21-year-old admitted with glucose 428 mg/dL.
Receiving regular insulin IV drip.


6. (Matrix)


Match insulin type to onset:


Regular insulin


NPH


Lispro


Onsets:


15 min

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