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NSC Chapter 5 Neuroscience 2025 | 100+ Questions on Synaptic Transmission, Neurotransmitters, Receptors

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This document offers a comprehensive review of Chapter 5: Synaptic Transmission for the NSC Neuroscience course (2025/2026), containing over 100 structured exam questions with correct answers. It is meticulously designed for students preparing for midterms or finals in neuroscience, biology, or pre-med programs. The material presents core concepts in both electrical and chemical synapses, offering precise definitions and mechanisms relevant to synaptic communication in the nervous system. Topics include: Electrical vs. chemical synapses, gap junctions, and postsynaptic potentials Structure and function of synaptic vesicles, secretory granules, and active zones Types of synapses (axodendritic, axosomatic, Gray’s type I/II, neuromuscular junction) Neurotransmitter classes: amino acids (GABA, glutamate), amines (dopamine, serotonin), and peptides (substance P, CCK) Neurotransmitter synthesis, release (via exocytosis), and reuptake Receptor types: transmitter-gated ion channels, G-protein-coupled receptors, metabotropic receptors Postsynaptic responses: EPSPs, IPSPs, spatial and temporal summation Synaptic modulation, inhibition (e.g., shunting), and pharmacological effects (agonists, antagonists) Historical insights such as Otto Loewi’s discovery of chemical signaling This document is highly valuable for students in: Neuroscience, Biology, or Psychology undergraduate programs Medical, Pre-Med, or Health Science courses focusing on neurobiology Learners preparing for exams covering neural signaling, synaptic integration, and neuropharmacology With well-structured Q&A format and clear scientific terminology, it enables efficient revision and deep understanding of nervous system signaling processes. Keywords: synaptic transmission, neurotransmitters, gap junctions, EPSP, IPSP, GABA, glutamate, dopamine, serotonin, neuromuscular junction, exocytosis, endocytosis, ion channels, G-protein, metabotropic receptors, Otto Loewi, spatial summation, temporal summation, receptor agonist, receptor antagonist, vesicle transport, neuropharmacology

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Uploaded on
November 28, 2025
Number of pages
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Written in
2025/2026
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NSC Ch. 5 2025/2026 Exam Questions
with 100% Correct Answers | Latest
Update



synaptic transmission - 🧠 ANSWER ✔✔process of information transfer at a

synapse




two types: electrical and chemical


electrical synapses - 🧠 ANSWER ✔✔synaptic transmission via electrical

current flowing from one neuron to the next

,occur through gap junctions that ions pass directly from cytoplasm of one

cell to cytoplasm of the other




at the junctions, channels called connexons (2 per channel) form gap

junction channels that ions pass through




transmission is bidirectional and very fast




when connected by by gap junctions, said to be electrically coupled




AP in the presynaptic neuron causes a small amount of ionic current to flow

across the gap junction channels into the other neuron causing PSP


chemical synapses - 🧠 ANSWER ✔✔chemical neurotransmitters transfer

information from one neuron to another at the synapse; most




presynaptic and postsynaptic membranse separated by synaptic cleft that's

filled with a matrix of fibrous extracellular protein

, presynaptic element usually an axon terminal, which contains dozens of

synaptic vesicles inside of which are neurotransmitters and the terminal

may also contain secretory vesicles


postsynaptic potential (PSP) - 🧠 ANSWER ✔✔AP caused in the second

neuron in an electrically coupled neurons


secretory granules - 🧠 ANSWER ✔✔large vesicles in axon terminals that

contain soluble protein that appears dark in the electron microscope




also called dense-core vesicles


membrane differentiations - 🧠 ANSWER ✔✔dense accumulations of protein

adjacent to and within the membrane on either side of the synaptic cleft


active zones - 🧠 ANSWER ✔✔sites of the neurotransmitter release; located

on the presynaptic side


postsynaptic density - 🧠 ANSWER ✔✔the protein thickly accumulated in

and just under the postsynaptic membrane




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