Comprehensive Questions and
Solutions Graded A+
a patient experiences very little drug effect when taking an active drug due to elevated enzyme
activity in their body. The patient would be known to be a/an - Answer: Ultra rapid metabolizer
what can affect bioavailability of a medication? - Answer: slowed stomach emptying
low blood pressure/shock
increased GI mobility
what is the study of how the body metabolizes and eliminates a particular drug? - Answer:
pharmacokinetics
Which drug administration and dosing regimen would have the most consistent level of plasma
concentration? - Answer: continuous IV infusion
What is a phenotype? - Answer: physical expression of genotype
which of the following is a reason why PCPs report they have never ordered PGx testing? -
Answer: lack of confidence in using PGx testing
A patient identified as a poor metabolizer (PM) has? - Answer: 2 inactive or loss-of-function
alleles
, competitive antagonist - Answer: a pharmacologic antagonist that can be overcome by
increasing the concentration of agonist
partial agonist - Answer: a drug that binds to a receptor and causes a response that is less than
that caused by a full agonist
Spare receptor - Answer: Receptor that does not bind drug when the drug concentration is
sufficient to produce maximal effect
Effector - Answer: Component of a system that accomplishes the biologic effect after the
receptor is activated by an agonist; often a channel, transporter, or enzyme molecule, may be
part of the receptor molecule
contraceptive medications are classified by - Answer: dose of drug
schedule of drug
hormonal make-up of drug (estrogen, progesterone)
What are adverse effects of combined oral contraceptive medications - Answer: headaches
weight gain
nausea
veracity - Answer: truthfulness
Confidentiality - Answer: the assurance that messages and information are available only to
those who are authorized to view them
privacy - Answer: the right of people not to reveal information about themselves