Terms in this set (113)
alcohol increases metabolic formation of active
metabolite, leading to easier therapy but increased
acetaminophen and alcohol hepatotoxicity
increased HR/contractility, peripheral resistance/BP,
bronchodilation, pupillary dilation/mydriasis, urinary
adrenergic stimulation retention, and sweating
alpha1 antagonism vasodilation, examples of drugs all end in -osin
epi nomally binds a1 and b2, but an a1 antagonst (-zosin)
will block epi-receptor binding there and not at b2,
alpha 1 antagonists and causing ONLY vasodilation (b2) with no vasocontriction
epinephrine (a1) thus decreasing the pulse
Alpha1 receptors found in all blood vessels, vasoconstriction
peripheral vascular SMOOTH muscle, vasoconstriction,
phenylephrine (nasal decongestant) and methoxamine for
alpha1 stimulation hypotension are specific for A1
, reduces outflow of NE, clonidine, methyldopa,
guanfacine, used for hypertension, ADHD, and drug
alpha2 stimulation withdrawal
antimuscarinic, neuromuscular jxn blockers, and
anticholinergic drugs ganglionic blocking drugs
antihistamines, MAO inhibitors, and Tricyclic
antidepressants (all work by anticholinergic activity),
antimuscarinic DDIs these will potentiate the action
decreased salivation, lacrimation, urination, defecation, GI
mobility, and bronchial constrictions, increased HR due to
block of vagal reflex, pupillary dilation (mydriasis),
drowsiness, hallucinations (dry as a bone, hot as hell, red
antimuscarinic drug effects as a beet, blind as a bat, mad as a hatter)
atropine and scopolamine, act as competitive receptor
blockers a postganglionic postsynaptic muscarinic
antimuscarinic drugs receptor sites
a cholinesterase inhibitor drug used to prolong the half life
of acetylecholine giving the transmitter a better ability to
aricept stimulate
selctive B1 blockers, decrease BP without
bronchoconstriction, good for hypertension (with diabetes
atenolol and metoprolol and asthma, wont hide symptoms), angina, or glaucoma
, found in the lungs, if stimulated there will be
Beta2 receptors bronchodilation
compares amount of drug that reaches the blood by non
IV routes vs amount of drug that reaches blood by IV (IV
(bottom number) is always 100)
bioavailability (conc. of nonIV/conc. of IV)
bioavailability formula question will be on exam
indirect acting drug, preventing release of Ach, reduces
wrinkles and gives some thereapy by inducing paralysis,
can be used dentally for something like bruxism or
botox esthetically for a gummy smile
chemical specificity for specificity between receptors and bonds, EX strict
receptors structural requirements for binding
sialagogue, DDI with drugs that inhibit 2D6 and 3A4 due
to the metabolism of this drug is through these two
cimeveline (evoxac) enzymes, contraindicated in those deficient in 2D6 also
body's ability to rid itself of a drug from plasma,
maximum clearance by liver/kidney is equal to total
clearance plasma flow through these organs (ml/min)
alcohol increases metabolic formation of active
metabolite, leading to easier therapy but increased
acetaminophen and alcohol hepatotoxicity
increased HR/contractility, peripheral resistance/BP,
bronchodilation, pupillary dilation/mydriasis, urinary
adrenergic stimulation retention, and sweating
alpha1 antagonism vasodilation, examples of drugs all end in -osin
epi nomally binds a1 and b2, but an a1 antagonst (-zosin)
will block epi-receptor binding there and not at b2,
alpha 1 antagonists and causing ONLY vasodilation (b2) with no vasocontriction
epinephrine (a1) thus decreasing the pulse
Alpha1 receptors found in all blood vessels, vasoconstriction
peripheral vascular SMOOTH muscle, vasoconstriction,
phenylephrine (nasal decongestant) and methoxamine for
alpha1 stimulation hypotension are specific for A1
, reduces outflow of NE, clonidine, methyldopa,
guanfacine, used for hypertension, ADHD, and drug
alpha2 stimulation withdrawal
antimuscarinic, neuromuscular jxn blockers, and
anticholinergic drugs ganglionic blocking drugs
antihistamines, MAO inhibitors, and Tricyclic
antidepressants (all work by anticholinergic activity),
antimuscarinic DDIs these will potentiate the action
decreased salivation, lacrimation, urination, defecation, GI
mobility, and bronchial constrictions, increased HR due to
block of vagal reflex, pupillary dilation (mydriasis),
drowsiness, hallucinations (dry as a bone, hot as hell, red
antimuscarinic drug effects as a beet, blind as a bat, mad as a hatter)
atropine and scopolamine, act as competitive receptor
blockers a postganglionic postsynaptic muscarinic
antimuscarinic drugs receptor sites
a cholinesterase inhibitor drug used to prolong the half life
of acetylecholine giving the transmitter a better ability to
aricept stimulate
selctive B1 blockers, decrease BP without
bronchoconstriction, good for hypertension (with diabetes
atenolol and metoprolol and asthma, wont hide symptoms), angina, or glaucoma
, found in the lungs, if stimulated there will be
Beta2 receptors bronchodilation
compares amount of drug that reaches the blood by non
IV routes vs amount of drug that reaches blood by IV (IV
(bottom number) is always 100)
bioavailability (conc. of nonIV/conc. of IV)
bioavailability formula question will be on exam
indirect acting drug, preventing release of Ach, reduces
wrinkles and gives some thereapy by inducing paralysis,
can be used dentally for something like bruxism or
botox esthetically for a gummy smile
chemical specificity for specificity between receptors and bonds, EX strict
receptors structural requirements for binding
sialagogue, DDI with drugs that inhibit 2D6 and 3A4 due
to the metabolism of this drug is through these two
cimeveline (evoxac) enzymes, contraindicated in those deficient in 2D6 also
body's ability to rid itself of a drug from plasma,
maximum clearance by liver/kidney is equal to total
clearance plasma flow through these organs (ml/min)
