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NBME Step 2 CK Practice Questions 2025: USMLE Clinical Knowledge Review

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Ace the USMLE Step 2 CK with our NBME-style practice questions. This 2025 review features clinical vignettes, detailed explanations for correct and incorrect answers, and systems-based blocks to target your study for the Clinical Knowledge exam.

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November 20, 2025
Number of pages
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Written in
2025/2026
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NBME Step 2CK Review Questions & Answers Latest

2025 ; 100% Correct & Verified.



What is initial tx? .....ANSWER..... Small cell lung cancer




-initial therapy is chemotherapy bc surgery has limited role given

that these tumors are nonresectable

27 YO male with cough , SOB, weight loss in 6 mons. PE shows

A/P Cervical LAD and white plaques over buccal mucosa

-CXR shows diffuse bilateral infiltrates




diagnosis? .....ANSWER..... AIDS




-pt has oral thrush, clear aids defining illness

,Page 2 of 43


25 YO woman wants to discuss risk for dementia




which of the following has greatest predisposing risk?

-fmhx

-gender

-head injury

-low educational level

-smoking

.....ANSWER..... family hx

72 YO woman undergoing rehab s/p 6 weeks after cerebral

infarction. Has urinary dribbling and palpable smooth mass in

supra public area

-UA shows 3-5 squamous epithelial cells/hpf

,Page 3 of 43


type of urinary incontinence .....ANSWER..... neurogenic bladder

urge incontinence




cause and management .....ANSWER..... due to detrusor

instability (think older nursing home patient) having the sudden

urge to void but only goes a little bit




manage with exercises first then anticholinergic medications

Stress incontinence




cause and diagnosis .....ANSWER..... weakness of pelvic

diaphragm (think women with multiple babies) urine with physical

movement

, Page 4 of 43


manage with Kegel exercises, estrogen therapy, pessary,

surgery (midurethral sling)

overflow incontinence




cause and diagnosis .....ANSWER..... inadequate bladder

contraction (think older person with neurologic deficit like DM or

stroke)




self Cath, cholinergic meds(increase contraction) , alpha blockers

(decrease sphincter resistance)

52 Yo mane comes because of 3 day fever, diffuse cervical LAD

and liver edge is 2cm below right costal margin, spleen is 2 cm

below.




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